ID   TIFAB_RAT               Reviewed;         147 AA.
AC   Q5BK67;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=TRAF-interacting protein with FHA domain-containing protein B;
DE   AltName: Full=TIFA-like protein;
GN   Name=Tifab {ECO:0000250|UniProtKB:Q6ZNK6};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAH91188.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen {ECO:0000312|EMBL:AAH91188.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inhibits TIFA-mediated TRAF6 activation possibly by inducing
CC       a conformational change in TIFA. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TIFA. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC091188; AAH91188.1; -; mRNA.
DR   RefSeq; NP_001020200.1; NM_001025029.1.
DR   RefSeq; XP_006253640.1; XM_006253578.3.
DR   RefSeq; XP_006253641.1; XM_006253579.3.
DR   RefSeq; XP_008769665.1; XM_008771443.2.
DR   AlphaFoldDB; Q5BK67; -.
DR   SMR; Q5BK67; -.
DR   STRING; 10116.ENSRNOP00000015878; -.
DR   PaxDb; Q5BK67; -.
DR   Ensembl; ENSRNOT00000015878; ENSRNOP00000015878; ENSRNOG00000011947.
DR   Ensembl; ENSRNOT00000116729; ENSRNOP00000083675; ENSRNOG00000011947.
DR   GeneID; 364674; -.
DR   KEGG; rno:364674; -.
DR   UCSC; RGD:1311681; rat.
DR   CTD; 497189; -.
DR   RGD; 1311681; Tifab.
DR   eggNOG; ENOG502SPI3; Eukaryota.
DR   GeneTree; ENSGT00940000154589; -.
DR   HOGENOM; CLU_116346_0_0_1; -.
DR   InParanoid; Q5BK67; -.
DR   OMA; KGCVWVN; -.
DR   OrthoDB; 1346020at2759; -.
DR   PhylomeDB; Q5BK67; -.
DR   TreeFam; TF333218; -.
DR   PRO; PR:Q5BK67; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000011947; Expressed in spleen and 19 other tissues.
DR   Genevisible; Q5BK67; RN.
DR   GO; GO:0031223; P:auditory behavior; ISO:RGD.
DR   GO; GO:0090102; P:cochlea development; ISO:RGD.
DR   GO; GO:0090103; P:cochlea morphogenesis; ISO:RGD.
DR   GO; GO:0097094; P:craniofacial suture morphogenesis; ISO:RGD.
DR   GO; GO:0048806; P:genitalia development; ISO:RGD.
DR   GO; GO:0035112; P:genitalia morphogenesis; ISO:RGD.
DR   GO; GO:1905748; P:hard palate morphogenesis; ISO:RGD.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; ISO:RGD.
DR   GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR   GO; GO:0098583; P:learned vocalization behavior; ISO:RGD.
DR   GO; GO:0071626; P:mastication; ISO:RGD.
DR   GO; GO:1901078; P:negative regulation of relaxation of muscle; ISO:RGD.
DR   GO; GO:1905747; P:negative regulation of saliva secretion; ISO:RGD.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; ISO:RGD.
DR   GO; GO:0030432; P:peristalsis; ISO:RGD.
DR   GO; GO:0048634; P:regulation of muscle organ development; ISO:RGD.
DR   GO; GO:0007356; P:thorax and anterior abdomen determination; ISO:RGD.
DR   GO; GO:0021559; P:trigeminal nerve development; ISO:RGD.
DR   GO; GO:0021650; P:vestibulocochlear nerve formation; ISO:RGD.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR033621; TIFA.
DR   PANTHER; PTHR31266; PTHR31266; 1.
DR   Pfam; PF00498; FHA; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..147
FT                   /note="TRAF-interacting protein with FHA domain-containing
FT                   protein B"
FT                   /id="PRO_0000320694"
FT   DOMAIN          36..108
FT                   /note="FHA"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   147 AA;  16666 MW;  F8B4BBB3A2ED832A CRC64;
     MERPLTVLQV SLYHPTQGPV AFAKVPLQLQ HDASRLLVGR GQDTHLQLQL PQLSRHHLCL
     EPYLEKGSNL LAFCLKVLTR QSCVWVNGLP LRYLEQVPLH SVNRISFSGI QMLIRKEGGA
     SLEAFVCYFH LSPSPLIYRP KAQETDE