ID   TIFA_XENTR              Reviewed;         177 AA.
AC   B5DE70;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=TRAF-interacting protein with FHA domain-containing protein A {ECO:0000305};
GN   Name=tifa {ECO:0000250|UniProtKB:Q96CG3};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter molecule that plays a key role in the activation of
CC       pro-inflammatory NF-kappa-B signaling following detection of bacterial
CC       pathogen-associated molecular pattern metabolites (PAMPs) (By
CC       similarity). Promotes activation of an innate immune response by
CC       inducing the oligomerization and polyubiquitination of TRAF6, which
CC       leads to the activation of TAK1 and IKK through a proteasome-
CC       independent mechanism (By similarity). {ECO:0000250|UniProtKB:Q2MHQ9,
CC       ECO:0000250|UniProtKB:Q96CG3}.
CC   -!- SUBUNIT: Interacts with traf6. {ECO:0000250|UniProtKB:Q2MHQ9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96CG3}.
CC   -!- SIMILARITY: Belongs to the TIFA family. {ECO:0000305}.
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DR   EMBL; BC168551; AAI68551.1; -; mRNA.
DR   RefSeq; NP_001135653.1; NM_001142181.1.
DR   AlphaFoldDB; B5DE70; -.
DR   SMR; B5DE70; -.
DR   STRING; 8364.ENSXETP00000052013; -.
DR   PaxDb; B5DE70; -.
DR   Ensembl; ENSXETT00000052013; ENSXETP00000052013; ENSXETG00000024109.
DR   GeneID; 100216213; -.
DR   KEGG; xtr:100216213; -.
DR   CTD; 92610; -.
DR   Xenbase; XB-GENE-951828; tifa.
DR   eggNOG; ENOG502S0RF; Eukaryota.
DR   HOGENOM; CLU_125520_0_0_1; -.
DR   InParanoid; B5DE70; -.
DR   OMA; MKMNCEH; -.
DR   OrthoDB; 1381983at2759; -.
DR   PhylomeDB; B5DE70; -.
DR   TreeFam; TF333218; -.
DR   Reactome; R-XTR-9645460; Alpha-protein kinase 1 signaling pathway.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024109; Expressed in egg cell and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR033621; TIFA.
DR   PANTHER; PTHR31266; PTHR31266; 1.
DR   Pfam; PF00498; FHA; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..177
FT                   /note="TRAF-interacting protein with FHA domain-containing
FT                   protein A"
FT                   /id="PRO_0000391617"
FT   DOMAIN          48..104
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
SQ   SEQUENCE   177 AA;  20614 MW;  FCF7D9341F78FCEF CRC64;
     MDETLNVDTE QTLTCLTLTM YHPNHQDQKL FRGINFSRKE EIKADAVVAF GRDYNVCRYP
     LLSNRVSRIQ FNLQFFKHFN CSTTAIEIKN LSKKNKLYVD NLELDYLNKI ELPPKCMIRF
     GDFQILAVIE RGDCDEKFEI CCEKSHVSLV QDSFIPTMQP IPECGTLNAV EIDENEY