TIG1_HUMAN
ID TIG1_HUMAN Reviewed; 294 AA.
AC P49788; Q8N1D7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Retinoic acid receptor responder protein 1;
DE AltName: Full=Phorbol ester-induced gene 1 protein;
DE Short=PERG-1;
DE AltName: Full=RAR-responsive protein TIG1;
DE AltName: Full=Tazarotene-induced gene 1 protein;
GN Name=RARRES1; Synonyms=PEIG1, TIG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLY-42.
RC TISSUE=Skin;
RX PubMed=8601727; DOI=10.1111/1523-1747.ep12340668;
RA Nagpal S., Patel S., Asano A.T., Johnson A.T., Duvic M.,
RA Chandraratna R.A.S.;
RT "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-
RT responsive gene in skin.";
RL J. Invest. Dermatol. 106:269-274(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8832110;
RA Cafferata E.G., Gonzalez-Guerrico A.M., Pivetta O.H., Santa-Coloma T.A.;
RT "Identification by differential display of a mRNA specifically induced by
RT 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma
RT cells.";
RL Cell. Mol. Biol. 42:797-804(1996).
RN [4]
RP FUNCTION, LACK OF GLYCOSYLATION, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP AGBL2; KIF11 AND MAPRE1.
RX PubMed=21303978; DOI=10.1158/0008-5472.can-10-2294;
RA Sahab Z.J., Hall M.D., Me Sung Y., Dakshanamurthy S., Ji Y., Kumar D.,
RA Byers S.W.;
RT "Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2
RT to regulate the alpha-tubulin tyrosination cycle.";
RL Cancer Res. 71:1219-1228(2011).
CC -!- FUNCTION: Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may
CC regulate the alpha-tubulin tyrosination cycle.
CC {ECO:0000269|PubMed:21303978}.
CC -!- SUBUNIT: Interacts with AGBL2, KIF11 and MAPRE1.
CC {ECO:0000269|PubMed:21303978}.
CC -!- INTERACTION:
CC P49788; P20155: SPINK2; NbExp=5; IntAct=EBI-25504187, EBI-10200479;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:21303978}; Single-
CC pass type III membrane protein {ECO:0000269|PubMed:21303978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=P49788-1; Sequence=Displayed;
CC Name=1;
CC IsoId=P49788-2; Sequence=VSP_010697, VSP_010698;
CC -!- INDUCTION: By tazarotene and by all the retinoic acid receptors tested.
CC -!- PTM: Not glycosylated.
CC -!- SIMILARITY: Belongs to the protease inhibitor I47 (latexin) family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/RARRES1ID42050ch3q25.html";
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DR EMBL; U27185; AAA99722.1; -; mRNA.
DR EMBL; BC029640; AAH29640.1; -; mRNA.
DR CCDS; CCDS3184.1; -. [P49788-1]
DR CCDS; CCDS54665.1; -. [P49788-2]
DR RefSeq; NP_002879.2; NM_002888.3. [P49788-2]
DR RefSeq; NP_996846.1; NM_206963.1. [P49788-1]
DR AlphaFoldDB; P49788; -.
DR SMR; P49788; -.
DR BioGRID; 111853; 31.
DR IntAct; P49788; 1.
DR STRING; 9606.ENSP00000237696; -.
DR DrugBank; DB00755; Tretinoin.
DR MEROPS; I47.002; -.
DR GlyGen; P49788; 1 site.
DR iPTMnet; P49788; -.
DR PhosphoSitePlus; P49788; -.
DR BioMuta; RARRES1; -.
DR DMDM; 57014141; -.
DR EPD; P49788; -.
DR jPOST; P49788; -.
DR MassIVE; P49788; -.
DR PaxDb; P49788; -.
DR PeptideAtlas; P49788; -.
DR PRIDE; P49788; -.
DR ProteomicsDB; 56117; -. [P49788-1]
DR ProteomicsDB; 56118; -. [P49788-2]
DR TopDownProteomics; P49788-2; -. [P49788-2]
DR Antibodypedia; 1295; 379 antibodies from 26 providers.
DR DNASU; 5918; -.
DR Ensembl; ENST00000237696.10; ENSP00000237696.5; ENSG00000118849.10. [P49788-1]
DR Ensembl; ENST00000479756.1; ENSP00000418556.1; ENSG00000118849.10. [P49788-2]
DR GeneID; 5918; -.
DR KEGG; hsa:5918; -.
DR MANE-Select; ENST00000237696.10; ENSP00000237696.5; NM_206963.2; NP_996846.1.
DR UCSC; uc003fci.4; human. [P49788-1]
DR CTD; 5918; -.
DR DisGeNET; 5918; -.
DR GeneCards; RARRES1; -.
DR HGNC; HGNC:9867; RARRES1.
DR HPA; ENSG00000118849; Tissue enhanced (fallopian tube, salivary gland).
DR MIM; 605090; gene.
DR neXtProt; NX_P49788; -.
DR OpenTargets; ENSG00000118849; -.
DR PharmGKB; PA34228; -.
DR VEuPathDB; HostDB:ENSG00000118849; -.
DR eggNOG; ENOG502S0TS; Eukaryota.
DR GeneTree; ENSGT00530000063813; -.
DR HOGENOM; CLU_083048_1_0_1; -.
DR InParanoid; P49788; -.
DR OMA; MWEKTTQ; -.
DR OrthoDB; 1129396at2759; -.
DR PhylomeDB; P49788; -.
DR TreeFam; TF332787; -.
DR PathwayCommons; P49788; -.
DR SignaLink; P49788; -.
DR SIGNOR; P49788; -.
DR BioGRID-ORCS; 5918; 9 hits in 1073 CRISPR screens.
DR ChiTaRS; RARRES1; human.
DR GeneWiki; RARRES1; -.
DR GenomeRNAi; 5918; -.
DR Pharos; P49788; Tbio.
DR PRO; PR:P49788; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P49788; protein.
DR Bgee; ENSG00000118849; Expressed in pericardium and 155 other tissues.
DR Genevisible; P49788; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ProtInc.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR009684; Prot_inh_latexin.
DR InterPro; IPR027261; TIG1.
DR PANTHER; PTHR28591; PTHR28591; 1.
DR Pfam; PF06907; Latexin; 1.
DR PIRSF; PIRSF011132; Prot_inh_latexin; 1.
DR PIRSF; PIRSF500784; TAG1; 1.
DR SUPFAM; SSF54403; SSF54403; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..294
FT /note="Retinoic acid receptor responder protein 1"
FT /id="PRO_0000191346"
FT TOPO_DOM 1..20
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..42
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 273..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 225..228
FT /note="KTND -> VRKT (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:8601727"
FT /id="VSP_010697"
FT VAR_SEQ 229..294
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:8601727"
FT /id="VSP_010698"
FT VARIANT 42
FT /note="D -> G (in dbSNP:rs7621322)"
FT /evidence="ECO:0000269|PubMed:8601727"
FT /id="VAR_060094"
FT VARIANT 158
FT /note="D -> V (in dbSNP:rs11919919)"
FT /id="VAR_053612"
FT CONFLICT 62
FT /note="A -> K (in Ref. 1; AAA99722)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 294 AA; 33285 MW; BDBA3E034F493032 CRC64;
MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ DAGVPRRLLQ
QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK VHVVFSTERY NPESLLQEGE
GRLGKCSARV FFKNQKPRPT INVTCTRLIE KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN
HGHIDPSLRL IWDLAFLGSS YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH
ELSTQEIIPC RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF
