TIGD1_HUMAN
ID TIGD1_HUMAN Reviewed; 591 AA.
AC Q96MW7; Q6P4D2; Q6PIF9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Tigger transposable element-derived protein 1;
GN Name=TIGD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- INTERACTION:
CC Q96MW7; Q92870-2: APBB2; NbExp=3; IntAct=EBI-9091586, EBI-21535880;
CC Q96MW7; P42858: HTT; NbExp=9; IntAct=EBI-9091586, EBI-466029;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
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DR EMBL; AK056329; BAB71153.1; -; mRNA.
DR EMBL; AC092165; AAY24104.1; -; Genomic_DNA.
DR EMBL; BC035143; AAH35143.2; -; mRNA.
DR EMBL; BC063500; AAH63500.2; -; mRNA.
DR CCDS; CCDS2495.1; -.
DR RefSeq; NP_663748.1; NM_145702.2.
DR AlphaFoldDB; Q96MW7; -.
DR SMR; Q96MW7; -.
DR BioGRID; 128345; 6.
DR DIP; DIP-61581N; -.
DR IntAct; Q96MW7; 5.
DR STRING; 9606.ENSP00000386186; -.
DR iPTMnet; Q96MW7; -.
DR PhosphoSitePlus; Q96MW7; -.
DR BioMuta; TIGD1; -.
DR DMDM; 74762678; -.
DR EPD; Q96MW7; -.
DR MassIVE; Q96MW7; -.
DR MaxQB; Q96MW7; -.
DR PaxDb; Q96MW7; -.
DR PeptideAtlas; Q96MW7; -.
DR PRIDE; Q96MW7; -.
DR ProteomicsDB; 77425; -.
DR Antibodypedia; 34434; 275 antibodies from 27 providers.
DR DNASU; 200765; -.
DR Ensembl; ENST00000408957.7; ENSP00000386186.3; ENSG00000221944.9.
DR GeneID; 200765; -.
DR KEGG; hsa:200765; -.
DR MANE-Select; ENST00000408957.7; ENSP00000386186.3; NM_145702.4; NP_663748.1.
DR UCSC; uc002vsy.3; human.
DR CTD; 200765; -.
DR DisGeNET; 200765; -.
DR GeneCards; TIGD1; -.
DR HGNC; HGNC:14523; TIGD1.
DR HPA; ENSG00000221944; Low tissue specificity.
DR MalaCards; TIGD1; -.
DR MIM; 612972; gene.
DR neXtProt; NX_Q96MW7; -.
DR OpenTargets; ENSG00000221944; -.
DR PharmGKB; PA38382; -.
DR VEuPathDB; HostDB:ENSG00000221944; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000155163; -.
DR HOGENOM; CLU_018294_1_4_1; -.
DR InParanoid; Q96MW7; -.
DR OMA; MNTRMIR; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q96MW7; -.
DR TreeFam; TF101131; -.
DR PathwayCommons; Q96MW7; -.
DR SignaLink; Q96MW7; -.
DR BioGRID-ORCS; 200765; 49 hits in 998 CRISPR screens.
DR ChiTaRS; TIGD1; human.
DR GenomeRNAi; 200765; -.
DR Pharos; Q96MW7; Tdark.
DR PRO; PR:Q96MW7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96MW7; protein.
DR Bgee; ENSG00000221944; Expressed in pigmented layer of retina and 157 other tissues.
DR Genevisible; Q96MW7; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..591
FT /note="Tigger transposable element-derived protein 1"
FT /id="PRO_0000272615"
FT DOMAIN 6..57
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 70..149
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 178..403
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 33..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 103..142
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 550..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 249
FT /note="N -> S (in Ref. 3; AAH35143)"
FT /evidence="ECO:0000305"
FT CONFLICT 302
FT /note="D -> G (in Ref. 3; AAH35143)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 591 AA; 67299 MW; 920CA1F0CF2805C9 CRC64;
MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV VNAKEKFLKE
VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL SQSLIQNKAL TLFNSMKAER
GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA QGEAASADVE AAASYPEALA KIIDEGGYTK
QQIFNVDETA FYWKKMPSRT FIAREEKSVP GFKASKDRLT LLLGANAAGD FKLKPMLIYH
SENPRALKNY TKSTLPVLYK WNSKARMTAH LFTAWFTEYF KPTVETYCSE KKIPFKILLL
IDNAPSHPRA LMEIYEEINV IFMPANTTSI LQPMDQGVIS TFKSYYLRNT FHKALAAMDS
DVSDGSGQSK LKTFWKGFTI LDAIKNIRDS WEEVKLSTLT GVWKKLIPTL IDDYEGFKTS
VEEVSADVVE IAKELELEVE PEDVTELLQS HDKTLTDEEL FLMDAQRKWF LEMESTPGED
AVNIVEMTTK DLEYYINLVD KAAAGFERID SNFERSSTVG KMLSNSIACY REIFHERKSQ
LMRKASPMSY FRKLPQPPQP SAATTLTSQQ PSTSRQDPPP AKRVRLTEGS D
