ID   TIGD2_MOUSE             Reviewed;         525 AA.
AC   Q0VBL1; Q505P7; Q6NV77;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Tigger transposable element-derived protein 2;
GN   Name=Tigd2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Brain, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC       ECO:0000255|PROSITE-ProRule:PRU00583}.
CC   -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC068272; AAH68272.1; -; mRNA.
DR   EMBL; BC094458; AAH94458.1; -; mRNA.
DR   EMBL; BC120592; AAI20593.1; -; mRNA.
DR   EMBL; BC125491; AAI25492.1; -; mRNA.
DR   CCDS; CCDS39500.1; -.
DR   RefSeq; NP_001074614.1; NM_001081145.1.
DR   AlphaFoldDB; Q0VBL1; -.
DR   SMR; Q0VBL1; -.
DR   STRING; 10090.ENSMUSP00000057223; -.
DR   iPTMnet; Q0VBL1; -.
DR   PhosphoSitePlus; Q0VBL1; -.
DR   EPD; Q0VBL1; -.
DR   MaxQB; Q0VBL1; -.
DR   PaxDb; Q0VBL1; -.
DR   PeptideAtlas; Q0VBL1; -.
DR   PRIDE; Q0VBL1; -.
DR   ProteomicsDB; 262821; -.
DR   Antibodypedia; 65566; 19 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000062626; ENSMUSP00000057223; ENSMUSG00000049232.
DR   GeneID; 68140; -.
DR   KEGG; mmu:68140; -.
DR   UCSC; uc009cdj.1; mouse.
DR   CTD; 166815; -.
DR   MGI; MGI:1915390; Tigd2.
DR   VEuPathDB; HostDB:ENSMUSG00000049232; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   GeneTree; ENSGT00940000162273; -.
DR   HOGENOM; CLU_018294_1_1_1; -.
DR   InParanoid; Q0VBL1; -.
DR   OMA; QWFDSQS; -.
DR   OrthoDB; 1343623at2759; -.
DR   PhylomeDB; Q0VBL1; -.
DR   TreeFam; TF101131; -.
DR   BioGRID-ORCS; 68140; 1 hit in 71 CRISPR screens.
DR   PRO; PR:Q0VBL1; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q0VBL1; protein.
DR   Bgee; ENSMUSG00000049232; Expressed in stroma of bone marrow and 222 other tissues.
DR   Genevisible; Q0VBL1; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   InterPro; IPR007889; HTH_Psq.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..525
FT                   /note="Tigger transposable element-derived protein 2"
FT                   /id="PRO_0000271089"
FT   DOMAIN          1..52
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DOMAIN          67..139
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   DOMAIN          168..385
FT                   /note="DDE-1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        28..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        100..132
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   525 AA;  59651 MW;  524E3A0BF38E1FFA CRC64;
     MLGKRKRVVL TIKDKLDIIK KLEEGNSFKK LSVLYGIGES TVRDIKKNKE RIINYANSSD
     PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQARFFF DALGMEGDFN
     ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AASEFCGNFQ EFVERENLLP EQIYGADQTG
     LFWKCLPTRT LAFDTDQSTC EYRTSRERII IMCCANATGS HKLNLCVVGK AKRPRAFKGT
     DLSNLPVTYF SQKSAWIEPS VLKQWFEKCF VPQVQKHLKS KGLREKAVLL LDFPAAHPAE
     ELLSSDDGRI IVKYLPPNVT SLIQPMSQGV LTTVKRYYRA GLIQKYMDEG NDPKTFWKNL
     TVLDAIYEAS RAWNQIRSNT ITRAWKKLFP GNEENPSVSI DEGAILAANL ATVLQNTEDC
     EHVNIENIEQ WFDSRSSGSN CQVLADIVGA ADRAKVTEQK PSRKTRKAEL NPEKHISHKA
     ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRRKQRIQ NKSHL