ID   TIGD3_HUMAN             Reviewed;         471 AA.
AC   Q6B0B8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Tigger transposable element-derived protein 3;
GN   Name=TIGD3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q6B0B8; Q9UL41: PNMA3; NbExp=3; IntAct=EBI-12140557, EBI-11278955;
CC       Q6B0B8; Q53GL6: RALY; NbExp=3; IntAct=EBI-12140557, EBI-9512693;
CC       Q6B0B8; Q86SE5-3: RALYL; NbExp=3; IntAct=EBI-12140557, EBI-11526555;
CC       Q6B0B8; Q08117-2: TLE5; NbExp=3; IntAct=EBI-12140557, EBI-11741437;
CC       Q6B0B8; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-12140557, EBI-10180829;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC       ECO:0000255|PROSITE-ProRule:PRU00583}.
CC   -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC074862; AAH74862.1; -; mRNA.
DR   CCDS; CCDS8101.1; -.
DR   RefSeq; NP_663771.1; NM_145719.2.
DR   AlphaFoldDB; Q6B0B8; -.
DR   SMR; Q6B0B8; -.
DR   BioGRID; 128641; 11.
DR   IntAct; Q6B0B8; 9.
DR   STRING; 9606.ENSP00000308354; -.
DR   BioMuta; TIGD3; -.
DR   DMDM; 74762295; -.
DR   MassIVE; Q6B0B8; -.
DR   PaxDb; Q6B0B8; -.
DR   PeptideAtlas; Q6B0B8; -.
DR   PRIDE; Q6B0B8; -.
DR   ProteomicsDB; 66205; -.
DR   Antibodypedia; 29772; 138 antibodies from 22 providers.
DR   DNASU; 220359; -.
DR   Ensembl; ENST00000309880.6; ENSP00000308354.5; ENSG00000173825.7.
DR   GeneID; 220359; -.
DR   KEGG; hsa:220359; -.
DR   MANE-Select; ENST00000309880.6; ENSP00000308354.5; NM_145719.3; NP_663771.1.
DR   UCSC; uc001odo.5; human.
DR   CTD; 220359; -.
DR   GeneCards; TIGD3; -.
DR   HGNC; HGNC:18334; TIGD3.
DR   HPA; ENSG00000173825; Tissue enhanced (brain, intestine, testis).
DR   MIM; 619084; gene.
DR   neXtProt; NX_Q6B0B8; -.
DR   OpenTargets; ENSG00000173825; -.
DR   PharmGKB; PA38527; -.
DR   VEuPathDB; HostDB:ENSG00000173825; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   GeneTree; ENSGT00940000162651; -.
DR   HOGENOM; CLU_018294_0_4_1; -.
DR   InParanoid; Q6B0B8; -.
DR   OMA; HKASEMP; -.
DR   OrthoDB; 1343623at2759; -.
DR   PhylomeDB; Q6B0B8; -.
DR   TreeFam; TF101131; -.
DR   PathwayCommons; Q6B0B8; -.
DR   SignaLink; Q6B0B8; -.
DR   BioGRID-ORCS; 220359; 24 hits in 1073 CRISPR screens.
DR   GenomeRNAi; 220359; -.
DR   Pharos; Q6B0B8; Tdark.
DR   PRO; PR:Q6B0B8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6B0B8; protein.
DR   Bgee; ENSG00000173825; Expressed in blood and 91 other tissues.
DR   Genevisible; Q6B0B8; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   InterPro; IPR007889; HTH_Psq.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..471
FT                   /note="Tigger transposable element-derived protein 3"
FT                   /id="PRO_0000271090"
FT   DOMAIN          3..55
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DOMAIN          67..137
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   DOMAIN          167..360
FT                   /note="DDE-1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        31..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        100..130
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   471 AA;  52027 MW;  82127423A95429B7 CRC64;
     MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK NKEKLLADWC
     SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP MLLHKAKELA DIMGQDFVPS
     IGWLVRWKRR NNVGFGARHV LAPSFPPEPP PPGLTSQAQL PLSLKDFSPE DVFGCAELPL
     LYRAVPGSFG ACDQVQVLLC ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG
     IPWLEWLAQF DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV
     VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK VPPQLIFSSF
     IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG EEPRSGVCKE EIGTEDEKGD
     REGAFEPLPT KADALRALGT LRRWFECNST SPELFEKFYD CEEEVERLCC L