ID   TIGD3_MOUSE             Reviewed;         470 AA.
AC   Q7TM95;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Tigger transposable element-derived protein 3;
GN   Name=Tigd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=129/Sv X 129SvCp, and C57BL/6J;
RC   TISSUE=Brain, and Embryonic stem cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC       ECO:0000255|PROSITE-ProRule:PRU00583}.
CC   -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC053500; AAH53500.1; -; mRNA.
DR   EMBL; BC055784; AAH55784.1; -; mRNA.
DR   CCDS; CCDS29483.1; -.
DR   RefSeq; NP_941036.1; NM_198634.1.
DR   RefSeq; XP_006531839.1; XM_006531776.3.
DR   AlphaFoldDB; Q7TM95; -.
DR   SMR; Q7TM95; -.
DR   STRING; 10090.ENSMUSP00000059302; -.
DR   PaxDb; Q7TM95; -.
DR   PRIDE; Q7TM95; -.
DR   Antibodypedia; 29772; 138 antibodies from 22 providers.
DR   DNASU; 332359; -.
DR   Ensembl; ENSMUST00000055911; ENSMUSP00000059302; ENSMUSG00000044390.
DR   Ensembl; ENSMUST00000236767; ENSMUSP00000157880; ENSMUSG00000044390.
DR   GeneID; 332359; -.
DR   KEGG; mmu:332359; -.
DR   UCSC; uc008gft.1; mouse.
DR   CTD; 220359; -.
DR   MGI; MGI:2681860; Tigd3.
DR   VEuPathDB; HostDB:ENSMUSG00000044390; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   GeneTree; ENSGT00940000162651; -.
DR   HOGENOM; CLU_018294_0_4_1; -.
DR   InParanoid; Q7TM95; -.
DR   OMA; HKASEMP; -.
DR   OrthoDB; 1343623at2759; -.
DR   PhylomeDB; Q7TM95; -.
DR   TreeFam; TF101131; -.
DR   BioGRID-ORCS; 332359; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Tigd3; mouse.
DR   PRO; PR:Q7TM95; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q7TM95; protein.
DR   Bgee; ENSMUSG00000044390; Expressed in medial ganglionic eminence and 162 other tissues.
DR   Genevisible; Q7TM95; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   InterPro; IPR007889; HTH_Psq.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..470
FT                   /note="Tigger transposable element-derived protein 3"
FT                   /id="PRO_0000271091"
FT   DOMAIN          3..55
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DOMAIN          67..137
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   DOMAIN          167..360
FT                   /note="DDE-1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        31..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        100..130
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          402..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   470 AA;  52223 MW;  FE9A57074FFA88AA CRC64;
     MELNTKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK NKEKLLADWC
     SGTANHERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP MLLHKAKELA DIMGQDFVPS
     IGWLVRWKRR NNVGFGTRQV LVPLFPPEAP PAVLPSQAQP PLSLKDFSPE DVFGCAEVPL
     LYRAVPGRVF ECDRLQVLLC ANSRGTEKRR VFVGGLQAAP RCFFGVSSEA LPTSYHPDLA
     IPWSEWLAQF DQDMGQQGRQ VALLLASGVV EEWASLPGLH HVRLLPLSAS STTPSLPGSV
     ILAFKAHYRH RLLSKLAAMQ SGKEGTSLAE ARASITVLDA LHMVAAAWAK VPRQLILSSF
     VQEGLAPGKT PLSLDKDTEM SPVPSGLSQE EFSHFVDLED EDPGPRVCKE ETGTEDSGRE
     EDGFEPLPTK ADALQALCTL RRWLECNSAS PELFEKFYDC EVEVEQLCCL