TIGD4_HUMAN
ID TIGD4_HUMAN Reviewed; 512 AA.
AC Q8IY51; Q96LP5;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Tigger transposable element-derived protein 4;
GN Name=TIGD4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-439.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-512.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- INTERACTION:
CC Q8IY51; Q12933: TRAF2; NbExp=3; IntAct=EBI-12117432, EBI-355744;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71642.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC106882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC037869; AAH37869.1; -; mRNA.
DR EMBL; AK058054; BAB71642.1; ALT_INIT; mRNA.
DR CCDS; CCDS34079.1; -.
DR RefSeq; NP_663772.1; NM_145720.3.
DR RefSeq; XP_005262864.1; XM_005262807.4.
DR AlphaFoldDB; Q8IY51; -.
DR SMR; Q8IY51; -.
DR BioGRID; 128403; 24.
DR IntAct; Q8IY51; 3.
DR STRING; 9606.ENSP00000355162; -.
DR GlyGen; Q8IY51; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IY51; -.
DR PhosphoSitePlus; Q8IY51; -.
DR BioMuta; TIGD4; -.
DR DMDM; 296452928; -.
DR MassIVE; Q8IY51; -.
DR PaxDb; Q8IY51; -.
DR PeptideAtlas; Q8IY51; -.
DR PRIDE; Q8IY51; -.
DR ProteomicsDB; 71111; -.
DR Antibodypedia; 27816; 86 antibodies from 21 providers.
DR DNASU; 201798; -.
DR Ensembl; ENST00000304337.3; ENSP00000355162.2; ENSG00000169989.3.
DR GeneID; 201798; -.
DR KEGG; hsa:201798; -.
DR MANE-Select; ENST00000304337.3; ENSP00000355162.2; NM_145720.4; NP_663772.1.
DR UCSC; uc003imy.3; human.
DR CTD; 201798; -.
DR DisGeNET; 201798; -.
DR GeneCards; TIGD4; -.
DR HGNC; HGNC:18335; TIGD4.
DR HPA; ENSG00000169989; Tissue enriched (retina).
DR neXtProt; NX_Q8IY51; -.
DR OpenTargets; ENSG00000169989; -.
DR PharmGKB; PA38528; -.
DR VEuPathDB; HostDB:ENSG00000169989; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000160195; -.
DR HOGENOM; CLU_018294_0_4_1; -.
DR InParanoid; Q8IY51; -.
DR OMA; QWMQKLD; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q8IY51; -.
DR TreeFam; TF101131; -.
DR PathwayCommons; Q8IY51; -.
DR SignaLink; Q8IY51; -.
DR BioGRID-ORCS; 201798; 20 hits in 1037 CRISPR screens.
DR GenomeRNAi; 201798; -.
DR Pharos; Q8IY51; Tdark.
DR PRO; PR:Q8IY51; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8IY51; protein.
DR Bgee; ENSG00000169989; Expressed in sperm and 98 other tissues.
DR Genevisible; Q8IY51; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..512
FT /note="Tigger transposable element-derived protein 4"
FT /id="PRO_0000272616"
FT DOMAIN 12..63
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 75..146
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 174..375
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 39..59
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 108..139
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 434..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 432
FT /note="A -> T (in dbSNP:rs34432931)"
FT /id="VAR_057509"
FT VARIANT 439
FT /note="I -> V (in dbSNP:rs4696354)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030042"
FT VARIANT 489
FT /note="Q -> R (in dbSNP:rs35581576)"
FT /id="VAR_057510"
FT CONFLICT 91
FT /note="L -> LSR (in Ref. 2; BAB71642)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 57468 MW; 212034AE45493CD2 CRC64;
MAEASVDAST LPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK NSLSSIMKNK
DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC LNVPVNGPML RLKANDFAQK
LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE ATGVPVDPST VWYQNVLPYY LNDYHPKNVF
NIKETGLLYR MLPTNTFAFK GETCSVGKLC KDRITLVVGT NMDGSEKLPL LVIGKKRTPH
CFKGLKSLPV CYEANRMAWM TSDVFEQWMR KLDEEFQAQQ RRVVIFVESF PAHPEVKNLK
SIELAFFPSC LSSKCIAMKQ GVIKSLKIKY RHCLIKKFLS SVEGSKEFTF SLLDAVDTLH
LCWRAVTPET IVKSYEEAGF KSQKGESDIT NAEKDTGLDL VADALGAGVE FPEGLSIEEY
AALDDDLETC EAAPNGDSIC TKESKSDETG FYTSDEEDDD GSPGTELPLP SKSEAITALD
TLKKFLRSQD MNDGLQNSLA DLENFINSLS PK
