TIGD4_MOUSE
ID TIGD4_MOUSE Reviewed; 513 AA.
AC Q8BUZ3;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Tigger transposable element-derived protein 4;
GN Name=Tigd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
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DR EMBL; AK081667; BAC38284.1; -; mRNA.
DR CCDS; CCDS17439.1; -.
DR RefSeq; NP_997161.1; NM_207278.2.
DR AlphaFoldDB; Q8BUZ3; -.
DR SMR; Q8BUZ3; -.
DR IntAct; Q8BUZ3; 4.
DR STRING; 10090.ENSMUSP00000052320; -.
DR iPTMnet; Q8BUZ3; -.
DR PhosphoSitePlus; Q8BUZ3; -.
DR PaxDb; Q8BUZ3; -.
DR PRIDE; Q8BUZ3; -.
DR ProteomicsDB; 262783; -.
DR Antibodypedia; 27816; 86 antibodies from 21 providers.
DR Ensembl; ENSMUST00000062623; ENSMUSP00000052320; ENSMUSG00000047819.
DR GeneID; 403175; -.
DR KEGG; mmu:403175; -.
DR UCSC; uc008pqh.1; mouse.
DR CTD; 201798; -.
DR MGI; MGI:2685264; Tigd4.
DR VEuPathDB; HostDB:ENSMUSG00000047819; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000160195; -.
DR HOGENOM; CLU_018294_0_4_1; -.
DR InParanoid; Q8BUZ3; -.
DR OMA; QWMQKLD; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q8BUZ3; -.
DR TreeFam; TF101131; -.
DR BioGRID-ORCS; 403175; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8BUZ3; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BUZ3; protein.
DR Bgee; ENSMUSG00000047819; Expressed in quadriceps femoris and 17 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..513
FT /note="Tigger transposable element-derived protein 4"
FT /id="PRO_0000272617"
FT DOMAIN 12..63
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 75..146
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 174..375
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 39..59
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 108..139
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 433..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 57472 MW; 8B756E0F693AD2A1 CRC64;
MAEASVDIGT QPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK NSLSSIMKNK
DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC LNVPVNGPML RLKANDFAQK
LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE ATGISIDPST VWYQNVLPYY LNDYHPKNVF
NVKETGLLYR MLPTNTFAFK GETCSVGKLC KDRITLALGT NMDGSEKLPL LIIGKNRAPR
CFKGIKSLPV YYEANRTAWM TAAIFEQWMQ KLDEKFQAQK RRVVIFVDSC PAHPEVKNLK
SIELAFFPSC LSSGFAAMNQ GVIKSLKIKY RHCLIKKFLS SVESSKEFTF SLLDAVDTLH
LCWRAVTPET IVKSYEEAGF RSPKGENDTA NADAAVALDL TAHAVGAGVE FLEGLSIEEY
AALDEDLETC EATQKDDAEW AGESKQDETG LYTSDEEEED SGALEVDLPS PSKKDALSAV
GTLKRFLRSH DLNDELHGSL ADLENFINAL SPK
