TIGD5_HUMAN
ID TIGD5_HUMAN Reviewed; 642 AA.
AC Q53EQ6; E7EWS2; Q6NT83; Q8N5A1; Q96JW8;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Tigger transposable element-derived protein 5;
GN Name=TIGD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 167-642 (ISOFORM 1/2), AND VARIANT ILE-568.
RC TISSUE=Mammary gland, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-642 (ISOFORM 1), AND VARIANT
RP ILE-568.
RC TISSUE=Kidney;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-642 (ISOFORMS 1/2), AND
RP VARIANT ILE-568.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- INTERACTION:
CC Q53EQ6-2; P50570-2: DNM2; NbExp=3; IntAct=EBI-10242213, EBI-10968534;
CC Q53EQ6-2; Q1RN33: MAGEA4; NbExp=3; IntAct=EBI-10242213, EBI-10194128;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q53EQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q53EQ6-2; Sequence=VSP_042796;
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32632.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB55398.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD97303.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC067930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032632; AAH32632.1; ALT_INIT; mRNA.
DR EMBL; BC069229; AAH69229.1; -; mRNA.
DR EMBL; AK223583; BAD97303.1; ALT_INIT; mRNA.
DR EMBL; AK027832; BAB55398.1; ALT_INIT; mRNA.
DR CCDS; CCDS6406.2; -. [Q53EQ6-1]
DR RefSeq; NP_116251.4; NM_032862.4. [Q53EQ6-1]
DR AlphaFoldDB; Q53EQ6; -.
DR SMR; Q53EQ6; -.
DR BioGRID; 124381; 324.
DR IntAct; Q53EQ6; 43.
DR STRING; 9606.ENSP00000421489; -.
DR iPTMnet; Q53EQ6; -.
DR PhosphoSitePlus; Q53EQ6; -.
DR BioMuta; TIGD5; -.
DR DMDM; 384872678; -.
DR EPD; Q53EQ6; -.
DR jPOST; Q53EQ6; -.
DR MassIVE; Q53EQ6; -.
DR MaxQB; Q53EQ6; -.
DR PaxDb; Q53EQ6; -.
DR PeptideAtlas; Q53EQ6; -.
DR PRIDE; Q53EQ6; -.
DR ProteomicsDB; 62445; -. [Q53EQ6-1]
DR ProteomicsDB; 62446; -. [Q53EQ6-2]
DR Antibodypedia; 43484; 35 antibodies from 14 providers.
DR DNASU; 84948; -.
DR Ensembl; ENST00000321385.5; ENSP00000315906.4; ENSG00000278016.2. [Q53EQ6-1]
DR Ensembl; ENST00000504548.4; ENSP00000421489.2; ENSG00000179886.6. [Q53EQ6-1]
DR GeneID; 84948; -.
DR KEGG; hsa:84948; -.
DR MANE-Select; ENST00000504548.4; ENSP00000421489.2; NM_032862.5; NP_116251.4.
DR UCSC; uc003yyx.3; human. [Q53EQ6-1]
DR CTD; 84948; -.
DR DisGeNET; 84948; -.
DR GeneCards; TIGD5; -.
DR HGNC; HGNC:18336; TIGD5.
DR HPA; ENSG00000179886; Low tissue specificity.
DR neXtProt; NX_Q53EQ6; -.
DR OpenTargets; ENSG00000179886; -.
DR VEuPathDB; HostDB:ENSG00000179886; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000154420; -.
DR HOGENOM; CLU_018294_1_1_1; -.
DR InParanoid; Q53EQ6; -.
DR OMA; PACYRYS; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q53EQ6; -.
DR TreeFam; TF338616; -.
DR PathwayCommons; Q53EQ6; -.
DR SignaLink; Q53EQ6; -.
DR BioGRID-ORCS; 84948; 13 hits in 1082 CRISPR screens.
DR ChiTaRS; TIGD5; human.
DR GenomeRNAi; 84948; -.
DR Pharos; Q53EQ6; Tdark.
DR PRO; PR:Q53EQ6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q53EQ6; protein.
DR Bgee; ENSG00000179886; Expressed in stromal cell of endometrium and 95 other tissues.
DR Genevisible; Q53EQ6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..642
FT /note="Tigger transposable element-derived protein 5"
FT /id="PRO_0000272618"
FT DOMAIN 47..98
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 112..185
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 233..357
FT /note="DDE-1 1"
FT /evidence="ECO:0000255"
FT DOMAIN 410..477
FT /note="DDE-1 2"
FT /evidence="ECO:0000255"
FT DNA_BIND 74..94
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 145..178
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..228
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..49
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042796"
FT VARIANT 568
FT /note="M -> I (in dbSNP:rs10282929)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_030043"
FT CONFLICT 91
FT /note="W -> C (in Ref. 3; BAD97303)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="G -> R (in Ref. 2; AAH69229)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="D -> G (in Ref. 4; BAB55398)"
FT /evidence="ECO:0000305"
FT CONFLICT 632
FT /note="G -> W (in Ref. 2; AAH32632)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 642 AA; 69222 MW; F805B9BA95C15CE3 CRC64;
MYPAGPPAGP VPRRGRRPLP GPPAPAPAPV PAARPPPPAP GPRPRVAVKM AFRKAYSIKD
KLQAIERVKG GERQASVCRD FGVPGGTLRG WLKDEPKLRW FLEQLGGEVG TQRKKMRLAN
EEEIDRAVYA WFLALRQHGV PLSGPLIQAQ AEAFARQIYG PECTFKASHG WFWRWQKRHG
ISSQRFYGEA GPPAPSPAPG PPVKEEPALP SGAGPLPDRA PAPPPPAEGG YGDEQIYSAS
VTGLYWKLLP EQAAPPGAGD PGAGGCGRRW RGDRVTVLLA ANLTGSHKLK PLVIGRLPDP
PSLRHHNQDK FPASYRYSPD AWLSRPLLRG WFFEEFVPGV KRYLRRSCLQ QKAVLLVAHP
PCPSPAASMP ALDSEDAPVR CRPEPLGPPE ELQTPDGAVR VLFLSKGSSR AHIPAPLEQG
VVAAFKQLYK RELLRLAVSC ASGSPLDFMR SFMLKDMLYL AGLSWDLVQA GSIERCWLLG
LRAAFEPRPG EDSAGQPAQA EEAAEHSRVL SDLTHLAALA YKCLAPEEVA EWLHLDDDGG
PPEGCREEVG PALPPAAPPA PASLPSAMGG GEDEEEATDY GGTSVPTAGE AVRGLETALR
WLENQDPREV GPLRLVQLRS LISMARRLGG IGHTPAGPYD GV
