TIGD5_MOUSE
ID TIGD5_MOUSE Reviewed; 642 AA.
AC Q499M4; Q8BQA1; Q8C381; Q8CBD5;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Tigger transposable element derived 5;
GN Name=Tigd5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Head, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q499M4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q499M4-2; Sequence=VSP_042797;
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29359.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC39713.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK051177; BAC34547.1; -; mRNA.
DR EMBL; AK086663; BAC39713.1; ALT_FRAME; mRNA.
DR EMBL; AK036241; BAC29359.1; ALT_FRAME; mRNA.
DR EMBL; BC099838; AAH99838.1; -; mRNA.
DR EMBL; BC138289; AAI38290.1; -; mRNA.
DR CCDS; CCDS79379.1; -. [Q499M4-1]
DR RefSeq; NP_848761.2; NM_178646.4. [Q499M4-1]
DR AlphaFoldDB; Q499M4; -.
DR SMR; Q499M4; -.
DR iPTMnet; Q499M4; -.
DR PhosphoSitePlus; Q499M4; -.
DR PeptideAtlas; Q499M4; -.
DR PRIDE; Q499M4; -.
DR ProteomicsDB; 259447; -. [Q499M4-1]
DR ProteomicsDB; 259448; -. [Q499M4-2]
DR Antibodypedia; 43484; 35 antibodies from 14 providers.
DR DNASU; 105734; -.
DR Ensembl; ENSMUST00000192937; ENSMUSP00000141473; ENSMUSG00000103906. [Q499M4-1]
DR GeneID; 105734; -.
DR KEGG; mmu:105734; -.
DR UCSC; uc007whp.1; mouse. [Q499M4-1]
DR CTD; 84948; -.
DR MGI; MGI:2145902; Tigd5.
DR VEuPathDB; HostDB:ENSMUSG00000103906; -.
DR GeneTree; ENSGT00940000154420; -.
DR HOGENOM; CLU_018294_1_1_1; -.
DR InParanoid; Q499M4; -.
DR OMA; PACYRYS; -.
DR OrthoDB; 1343623at2759; -.
DR BioGRID-ORCS; 105734; 2 hits in 65 CRISPR screens.
DR PRO; PR:Q499M4; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q499M4; protein.
DR Bgee; ENSMUSG00000103906; Expressed in femorotibial joint and 236 other tissues.
DR Genevisible; Q499M4; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..642
FT /note="Tigger transposable element derived 5"
FT /id="PRO_0000416768"
FT DOMAIN 57..108
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 122..195
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 240..365
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 84..104
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 155..188
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..54
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 418..642
FT /note="SRAHIPAPLEHGVVAAFKHLYKRELLRLAVSCASGSPLDFMRSFVLKDMLYL
FT AGLSWDLVQAGSIERCWLLGLRAAFEPGQQPAHQVEETAEHSRVLSDLTHLAALAYKRL
FT APEEVAQWLHLDDDGGLPEGCREEVAPAAPPSPASLPSSIGAGEEEEEATEQGGVLVPT
FT AGEAVWGLETALRWLESQDPREVGPLRLVQLRSLITMARRLGGIGPSAVTSDDGV ->
FT VGARRGGSLQAFVQTRAPAACCVLCQWLPSGLHEKLRSQGHAVPGWPLLGLGPGRQHRA
FT LLAAGSASSL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042797"
FT CONFLICT 44
FT /note="Missing (in Ref. 1; BAC29359)"
FT /evidence="ECO:0000305"
FT CONFLICT 436
FT /note="H -> R (in Ref. 1; BAC29359)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 642 AA; 70249 MW; 5281A7CF947FDEDE CRC64;
MYPASPPAGP ALHPVPHRAR LPQPRCLAEP PRSPAPGPGS TARPPPPPAP GPRPRVAVKM
TFRKAYSIKD KLQAIERVKG GERQASVCRD FGVPGGTLRG WLKDEPKLRW FLDQLGGEVG
TQRKKMRLAN EEEIDRAVYS WFLTLRQHGV PLSGPVIQAQ AEAFARQIYG PECTFKASHG
WFWRWQKRHG ISSQRIYGEA ESPVAGPAPV KEEPAQSPGA VLVPDGAPAT LPHSEGGYGD
EQIYNANVTG LYWRLLPEQA STPGTGDSKE PGGCSRRWRS DRVTVLLAAN LTGSHKLKPL
VIGQLPDPPS LRHHNQDKFP ASYRYSPDAW LSRPLLRGWF FEEFVPGVKR YLRRSCLQQK
AVLLVAHPPC PSWATSMPPL EESEETPRQC QPELLGSPEE LQTPDGAVRV LFLSKGTSRA
HIPAPLEHGV VAAFKHLYKR ELLRLAVSCA SGSPLDFMRS FVLKDMLYLA GLSWDLVQAG
SIERCWLLGL RAAFEPGQQP AHQVEETAEH SRVLSDLTHL AALAYKRLAP EEVAQWLHLD
DDGGLPEGCR EEVAPAAPPS PASLPSSIGA GEEEEEATEQ GGVLVPTAGE AVWGLETALR
WLESQDPREV GPLRLVQLRS LITMARRLGG IGPSAVTSDD GV
