ID   TIGD6_HUMAN             Reviewed;         521 AA.
AC   Q17RP2; B3KTZ8; Q96MQ4; Q9H0X7;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Tigger transposable element-derived protein 6;
GN   Name=TIGD6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-327.
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC       family. {ECO:0000305}.
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DR   EMBL; AL136539; CAB66474.1; -; mRNA.
DR   EMBL; AK056604; BAB71230.1; -; mRNA.
DR   EMBL; AK096325; BAG53260.1; -; mRNA.
DR   EMBL; CR533559; CAG38590.1; -; mRNA.
DR   EMBL; BC117249; AAI17250.1; -; mRNA.
DR   CCDS; CCDS4301.1; -.
DR   RefSeq; NP_001230182.1; NM_001243253.1.
DR   RefSeq; NP_112215.1; NM_030953.3.
DR   AlphaFoldDB; Q17RP2; -.
DR   SMR; Q17RP2; -.
DR   BioGRID; 123582; 25.
DR   IntAct; Q17RP2; 20.
DR   STRING; 9606.ENSP00000296736; -.
DR   GlyConnect; 2085; 3 N-Linked glycans (1 site).
DR   GlyGen; Q17RP2; 1 site, 6 N-linked glycans (1 site).
DR   iPTMnet; Q17RP2; -.
DR   PhosphoSitePlus; Q17RP2; -.
DR   BioMuta; TIGD6; -.
DR   DMDM; 124053415; -.
DR   jPOST; Q17RP2; -.
DR   MassIVE; Q17RP2; -.
DR   PaxDb; Q17RP2; -.
DR   PeptideAtlas; Q17RP2; -.
DR   PRIDE; Q17RP2; -.
DR   ProteomicsDB; 61161; -.
DR   Antibodypedia; 49916; 7 antibodies from 6 providers.
DR   DNASU; 81789; -.
DR   Ensembl; ENST00000296736.4; ENSP00000296736.3; ENSG00000164296.7.
DR   Ensembl; ENST00000515406.2; ENSP00000425318.2; ENSG00000164296.7.
DR   GeneID; 81789; -.
DR   KEGG; hsa:81789; -.
DR   MANE-Select; ENST00000296736.4; ENSP00000296736.3; NM_030953.4; NP_112215.1.
DR   UCSC; uc003lri.4; human.
DR   CTD; 81789; -.
DR   GeneCards; TIGD6; -.
DR   HGNC; HGNC:18332; TIGD6.
DR   HPA; ENSG00000164296; Low tissue specificity.
DR   neXtProt; NX_Q17RP2; -.
DR   OpenTargets; ENSG00000164296; -.
DR   PharmGKB; PA38525; -.
DR   VEuPathDB; HostDB:ENSG00000164296; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   GeneTree; ENSGT00940000163700; -.
DR   HOGENOM; CLU_018294_0_4_1; -.
DR   InParanoid; Q17RP2; -.
DR   OMA; AWWSVKQ; -.
DR   OrthoDB; 1343623at2759; -.
DR   PhylomeDB; Q17RP2; -.
DR   TreeFam; TF101131; -.
DR   PathwayCommons; Q17RP2; -.
DR   SignaLink; Q17RP2; -.
DR   BioGRID-ORCS; 81789; 10 hits in 1077 CRISPR screens.
DR   GenomeRNAi; 81789; -.
DR   Pharos; Q17RP2; Tdark.
DR   PRO; PR:Q17RP2; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q17RP2; protein.
DR   Bgee; ENSG00000164296; Expressed in islet of Langerhans and 106 other tissues.
DR   Genevisible; Q17RP2; HS.
DR   GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   InterPro; IPR007889; HTH_Psq.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..521
FT                   /note="Tigger transposable element-derived protein 6"
FT                   /id="PRO_0000272619"
FT   DOMAIN          3..54
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DOMAIN          66..137
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   DOMAIN          170..372
FT                   /note="DDE-1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        30..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        99..130
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   VARIANT         59
FT                   /note="R -> W (in dbSNP:rs9324636)"
FT                   /id="VAR_030044"
FT   VARIANT         327
FT                   /note="Q -> R (in dbSNP:rs10875553)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_030045"
FT   CONFLICT        6
FT                   /note="N -> K (in Ref. 2; BAB71230)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   521 AA;  58656 MW;  2C0526E08036324A CRC64;
     MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE
     ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS
     VGWLNRFRDR HGIALKAVCR EDSDRLMNGL GIDKINEWHA GEIIKLIADY SPDDIFNADE
     TGVFFQLLPQ HTLAAKGDHC RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN
     IHSLPCDYRA NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV
     GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK QAIDMIAAAW
     WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK LWHTVAIATC VPNEVNFQDF
     VTADDDLIIS QDTDIIQDMV AGENTSEAGS EDEGEVSLPE QPKVTITEAI SSVQKLRQFL
     STCVDIPDAI FGQLNGIDEY LMKRVTQTLI DSKITDFLQT K