TIGD7_HUMAN
ID TIGD7_HUMAN Reviewed; 549 AA.
AC Q6NT04; Q9BXZ0;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Tigger transposable element-derived protein 7;
GN Name=TIGD7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=15487591; DOI=10.1023/b:bigi.0000034428.95802.35;
RA Dou T., Gu S., Zhou Z., Ji C., Zeng L., Ye X., Xu J., Ying K., Xie Y.,
RA Mao Y.;
RT "Isolation and characterization of a Jerky and JRK/JH8 like gene, tigger
RT transposable element derived 7, TIGD7.";
RL Biochem. Genet. 42:279-285(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6NT04; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-3916512, EBI-743796;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NT04-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NT04-2; Sequence=VSP_022453;
CC -!- TISSUE SPECIFICITY: Expressed in all tissues tested. Higher expression
CC in testis and ovary. {ECO:0000269|PubMed:15487591}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
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DR EMBL; AF251050; AAK34940.1; -; mRNA.
DR EMBL; BC069632; AAH69632.1; -; mRNA.
DR EMBL; BC069623; AAH69623.1; -; mRNA.
DR CCDS; CCDS10500.1; -. [Q6NT04-1]
DR RefSeq; NP_149985.2; NM_033208.3. [Q6NT04-1]
DR AlphaFoldDB; Q6NT04; -.
DR SMR; Q6NT04; -.
DR BioGRID; 124801; 7.
DR IntAct; Q6NT04; 6.
DR STRING; 9606.ENSP00000380071; -.
DR iPTMnet; Q6NT04; -.
DR PhosphoSitePlus; Q6NT04; -.
DR BioMuta; TIGD7; -.
DR DMDM; 74762337; -.
DR EPD; Q6NT04; -.
DR MassIVE; Q6NT04; -.
DR PaxDb; Q6NT04; -.
DR PeptideAtlas; Q6NT04; -.
DR PRIDE; Q6NT04; -.
DR ProteomicsDB; 66649; -. [Q6NT04-1]
DR ProteomicsDB; 66650; -. [Q6NT04-2]
DR Antibodypedia; 49972; 50 antibodies from 14 providers.
DR DNASU; 91151; -.
DR Ensembl; ENST00000396862.2; ENSP00000380071.1; ENSG00000140993.11. [Q6NT04-1]
DR GeneID; 91151; -.
DR KEGG; hsa:91151; -.
DR MANE-Select; ENST00000396862.2; ENSP00000380071.1; NM_033208.4; NP_149985.2.
DR UCSC; uc002cus.4; human. [Q6NT04-1]
DR CTD; 91151; -.
DR GeneCards; TIGD7; -.
DR HGNC; HGNC:18331; TIGD7.
DR HPA; ENSG00000140993; Low tissue specificity.
DR MIM; 612969; gene.
DR neXtProt; NX_Q6NT04; -.
DR OpenTargets; ENSG00000140993; -.
DR PharmGKB; PA38524; -.
DR VEuPathDB; HostDB:ENSG00000140993; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000163295; -.
DR HOGENOM; CLU_018294_1_1_1; -.
DR InParanoid; Q6NT04; -.
DR OMA; DICLPGK; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q6NT04; -.
DR TreeFam; TF101131; -.
DR PathwayCommons; Q6NT04; -.
DR SignaLink; Q6NT04; -.
DR BioGRID-ORCS; 91151; 13 hits in 1083 CRISPR screens.
DR ChiTaRS; TIGD7; human.
DR GenomeRNAi; 91151; -.
DR Pharos; Q6NT04; Tdark.
DR PRO; PR:Q6NT04; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6NT04; protein.
DR Bgee; ENSG00000140993; Expressed in tendon of biceps brachii and 153 other tissues.
DR ExpressionAtlas; Q6NT04; baseline and differential.
DR Genevisible; Q6NT04; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..549
FT /note="Tigger transposable element-derived protein 7"
FT /id="PRO_0000272620"
FT DOMAIN 1..52
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 68..139
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 169..399
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 28..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 101..132
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 527..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 505..549
FT /note="KEMQQEIVKKQFQSKIHSRIGSFLKPRPHNIKDSFSGPSTSGSNH -> CEF
FT SDDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15487591"
FT /id="VSP_022453"
FT CONFLICT 207
FT /note="K -> T (in Ref. 1; AAK34940)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="T -> S (in Ref. 1; AAK34940)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 549 AA; 63236 MW; D3F806AEE808BF5F CRC64;
MNKRGKYTTL NLEEKMKVLS RIEAGRSLKS VMDEFGISKS TFYDIKKNKK LILDFVLKQD
MPLVGAEKRK RTTGAKYGDV DDAVYMWYQQ KRSAGVPVRG VELQAAAERF ARCFGRTDFK
ASTGWLFRFR NRHAIGNRKG CGEQVLSSVS ENVEPFRQKL SMIIKEEKLC LAQLYSGDET
DLFWKSMPEN SQASRKDICL PGKKINKERL SAFLCANADG THKLKSIIIG KSKLPKSVKE
DTSTLPVIYK PSKDVWFTRE LFSEWFFQNF VPEVRHFQLN VLRFHDEDVR ALLLLDSCPA
HPSSESLTSE DGRIKCMFFP HNTSTLIQPM NQGVILSCKR LYRWKQLEES LVIFEESDDE
QEKGDKGVSK IKIYNIKSAI FNWAKSWEEV KQITIANAWE NLLYKKEPEY DFQGLEHGDY
REILEKCGEL ETKLDDDRVW LNGDEEKGCL LKTKGGITKE VVQKGGEAEK QTAEFKLSAV
RESLDYLLDF VDATPEFQRF HFTLKEMQQE IVKKQFQSKI HSRIGSFLKP RPHNIKDSFS
GPSTSGSNH
