ID   BSAZ_BURM9              Reviewed;         411 AA.
AC   A2S1P8; A2S1P6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Secretion apparatus protein BsaZ;
GN   Name=bsaZ; OrderedLocusNames=BMA10229_2069;
OS   Burkholderia mallei (strain NCTC 10229).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=412022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 10229;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Part of the bsa type III secretion system, is involved in the
CC       intracellular replication of invading bacteria inside the host cell.
CC       Probably necessary for the lysis of the vacuole membrane and escape
CC       into the host cell cytoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC       {ECO:0000305}.
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DR   EMBL; CP000545; ABM99347.2; -; Genomic_DNA.
DR   RefSeq; WP_004188512.1; NC_008835.1.
DR   AlphaFoldDB; A2S1P8; -.
DR   SMR; A2S1P8; -.
DR   EnsemblBacteria; ABM99347; ABM99347; BMA10229_2069.
DR   GeneID; 56597879; -.
DR   KEGG; bml:BMA10229_2069; -.
DR   HOGENOM; CLU_041013_1_3_4; -.
DR   OMA; QPNPGAY; -.
DR   Proteomes; UP000002283; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.1690.10; -; 1.
DR   InterPro; IPR006307; BsaZ.
DR   InterPro; IPR006135; T3SS_substrate_exporter.
DR   InterPro; IPR029025; T3SS_substrate_exporter_C.
DR   PANTHER; PTHR30531; PTHR30531; 1.
DR   Pfam; PF01312; Bac_export_2; 1.
DR   PRINTS; PR00950; TYPE3IMSPROT.
DR   SUPFAM; SSF160544; SSF160544; 1.
DR   TIGRFAMs; TIGR01404; FlhB_rel_III; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..411
FT                   /note="Secretion apparatus protein BsaZ"
FT                   /id="PRO_0000344013"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          341..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44494 MW;  BF3CE62D4E6D48CD CRC64;
     MAEKTEKPTA KKLRDAAKKG QTFKARDIVA LIVIATGALA APALVDLTRI AAEFVRIAST
     GAQSNPGAYA FAWAKLFLRI AAPFVLLCAA AGALPSLVQS RFTLAVESIR FDLTALDPVK
     GMKRLFSWRS AKDAVKALLY VGVFALTVRV FADLYHADVF GLFRARPALL GHMWIVLTVR
     LVLLFLLCAL PVLILDAAVE YFLYHRELKM DKHEVKQEYK ESEGNHEIKS KRREIHQELL
     SEEIKANVEQ SDFIVANPTH IAIGVYVNPD IVPIPFVSVR ETNARALAVI RHAEACGVPV
     VRNVALARSI YRNSPRRYSF VSHDDIDGVM RVLIWLGEVE AANRGGPPPE TRAPTSAEPQ
     ARDGVAPLGD ACADNAFPDD APPGAAAPNA GSPDSPAPDG GAPARTGDQN A