ID   BSAZ_BURP2              Reviewed;         411 AA.
AC   I1WUC2;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Secretion apparatus protein BsaZ;
GN   Name=bsaZ; OrderedLocusNames=BP1026B_II1630;
OS   Burkholderia pseudomallei (strain 1026b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=884204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1026b;
RX   PubMed=22615773; DOI=10.1371/journal.pone.0036507;
RA   Hayden H.S., Lim R., Brittnacher M.J., Sims E.H., Ramage E.R., Fong C.,
RA   Wu Z., Crist E., Chang J., Zhou Y., Radey M., Rohmer L., Haugen E.,
RA   Gillett W., Wuthiekanun V., Peacock S.J., Kaul R., Miller S.I., Manoil C.,
RA   Jacobs M.A.;
RT   "Evolution of Burkholderia pseudomallei in recurrent melioidosis.";
RL   PLoS ONE 7:E36507-E36507(2012).
RN   [2]
RP   ROLE IN ESCAPE FROM VACUOLES.
RC   STRAIN=1026b;
RX   PubMed=18443088; DOI=10.1128/iai.00263-08;
RA   Burtnick M.N., Brett P.J., Nair V., Warawa J.M., Woods D.E.,
RA   Gherardini F.C.;
RT   "Burkholderia pseudomallei type III secretion system mutants exhibit
RT   delayed vacuolar escape phenotypes in RAW 264.7 murine macrophages.";
RL   Infect. Immun. 76:2991-3000(2008).
CC   -!- FUNCTION: Part of the bsa type III secretion system, is involved in the
CC       intracellular replication of invading bacteria inside the host cell.
CC       Probably necessary for the lysis of the vacuole membrane and escape
CC       into the host cell cytoplasm. {ECO:0000269|PubMed:18443088}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC       {ECO:0000305}.
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DR   EMBL; CP002834; AFI69866.1; -; Genomic_DNA.
DR   RefSeq; WP_004530588.1; NZ_CP004380.1.
DR   AlphaFoldDB; I1WUC2; -.
DR   SMR; I1WUC2; -.
DR   EnsemblBacteria; AFI69866; AFI69866; BP1026B_II1630.
DR   KEGG; bpz:BP1026B_II1630; -.
DR   PATRIC; fig|884204.3.peg.6016; -.
DR   Proteomes; UP000010087; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.1690.10; -; 1.
DR   InterPro; IPR006307; BsaZ.
DR   InterPro; IPR006135; T3SS_substrate_exporter.
DR   InterPro; IPR029025; T3SS_substrate_exporter_C.
DR   PANTHER; PTHR30531; PTHR30531; 1.
DR   Pfam; PF01312; Bac_export_2; 1.
DR   PRINTS; PR00950; TYPE3IMSPROT.
DR   SUPFAM; SSF160544; SSF160544; 1.
DR   TIGRFAMs; TIGR01404; FlhB_rel_III; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..411
FT                   /note="Secretion apparatus protein BsaZ"
FT                   /id="PRO_0000429785"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          341..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44400 MW;  3E2EDCFA2830C92F CRC64;
     MAEKTEKPTA KKLRDAAKKG QTFKARDIVA LIVIATGALA APALVDLTRI AAEFVRIAST
     GAQPNPGAYA FAWAKLFLRI AAPFVLLCAA AGALPSLVQS RFTLAVESIR FDLTALDPVK
     GMKRLFSWRS AKDAVKALLY VGVFALTVRV FAGLYHADVF GLFRARPALL GHMWIVLTVR
     LVLLFLLCAL PVLILDAAVE YFLYHRELKM DKHEVKQEYK ESEGNHEIKS KRREIHQELL
     SEEIKANVEQ SDFIVANPTH IAIGVYVNPD IVPIPFVSVR ETNARALAVI RHAEACGVPV
     VRNVALARSI YRNSPRRYSF VSHDDIDGVM RVLIWLGEVE AANRGGPPPE TRAPTSAEPQ
     ARDGVAPPGD ACADNAFPDD APPGAAAPNA GSPDGPAPDG GAPARTGDQN A