ID   BSAZ_BURPS              Reviewed;         411 AA.
AC   Q63K32;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Secretion apparatus protein BsaZ;
GN   Name=bsaZ; OrderedLocusNames=BPSS1534;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
RN   [2]
RP   ROLE IN LYSIS OF HOST VACUOLES.
RC   STRAIN=10276;
RX   PubMed=12410823; DOI=10.1046/j.1365-2958.2002.03190.x;
RA   Stevens M.P., Wood M.W., Taylor L.A., Monaghan P., Hawes P., Jones P.W.,
RA   Wallis T.S., Galyov E.E.;
RT   "An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia
RT   pseudomallei modulates intracellular behaviour of the pathogen.";
RL   Mol. Microbiol. 46:649-659(2002).
CC   -!- FUNCTION: Part of the bsa type III secretion system, is involved in the
CC       intracellular replication of invading bacteria inside the host cell.
CC       Probably necessary for the lysis of the vacuole membrane and escape
CC       into the host cell cytoplasm. {ECO:0000269|PubMed:12410823}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC       {ECO:0000305}.
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DR   EMBL; BX571966; CAH39007.1; -; Genomic_DNA.
DR   RefSeq; WP_004525318.1; NZ_CP009537.1.
DR   RefSeq; YP_111540.1; NC_006351.1.
DR   AlphaFoldDB; Q63K32; -.
DR   SMR; Q63K32; -.
DR   STRING; 272560.BPSS1534; -.
DR   MEROPS; N06.002; -.
DR   EnsemblBacteria; CAH39007; CAH39007; BPSS1534.
DR   KEGG; bps:BPSS1534; -.
DR   PATRIC; fig|272560.51.peg.4889; -.
DR   eggNOG; COG1377; Bacteria.
DR   OMA; QPNPGAY; -.
DR   PHI-base; PHI:5324; -.
DR   Proteomes; UP000000605; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.1690.10; -; 1.
DR   InterPro; IPR006307; BsaZ.
DR   InterPro; IPR006135; T3SS_substrate_exporter.
DR   InterPro; IPR029025; T3SS_substrate_exporter_C.
DR   PANTHER; PTHR30531; PTHR30531; 1.
DR   Pfam; PF01312; Bac_export_2; 1.
DR   PRINTS; PR00950; TYPE3IMSPROT.
DR   SUPFAM; SSF160544; SSF160544; 1.
DR   TIGRFAMs; TIGR01404; FlhB_rel_III; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..411
FT                   /note="Secretion apparatus protein BsaZ"
FT                   /id="PRO_0000344011"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          341..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44458 MW;  3E2EDC47B830C830 CRC64;
     MAEKTEKPTA KKLRDAAKKG QTFKARDIVA LIVIATGALA APALVDLTRI AAEFVRIAST
     GAQPNPGAYA FAWAKLFLRI AAPFVLLCAA AGALPSLVQS RFTLAVESIR FDLTALDPVK
     GMKRLFSWRS AKDAVKALLY VGVFALTVRV FADLYHADVF GLFRARPALL GHMWIVLTVR
     LVLLFLLCAL PVLILDAAVE YFLYHRELKM DKHEVKQEYK ESEGNHEIKS KRREIHQELL
     SEEIKANVEQ SDFIVANPTH IAIGVYVNPD IVPIPFVSVR ETNARALAVI RHAEACGVPV
     VRNVALARSI YRNSPRRYSF VSHDDIDGVM RVLIWLGEVE AANRGGPPPE TRAPTSAEPQ
     ARDGVAPPGD ACADNAFPDD APPGAAAPNA GSPDGPAPDG GAPARTGDQN A