ID   TIG_CHLTR               Reviewed;         442 AA.
AC   O84713;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Trigger factor;
DE            Short=TF;
DE            EC=5.2.1.8;
DE   AltName: Full=PPIase;
GN   Name=tig; OrderedLocusNames=CT_707;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Involved in protein export. Acts as a chaperone by
CC       maintaining the newly synthesized protein in an open conformation.
CC       Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=About half TF is bound to the
CC       ribosome near the polypeptide exit tunnel while the other half is free
CC       in the cytoplasm. {ECO:0000250}.
CC   -!- DOMAIN: Consists of 3 domains; the N-terminus binds the ribosome, the
CC       middle domain has PPIase activity, while the C-terminus has intrinsic
CC       chaperone activity on its own. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FKBP-type PPIase family. Tig subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE001273; AAC68302.1; -; Genomic_DNA.
DR   PIR; D71481; D71481.
DR   RefSeq; NP_220226.1; NC_000117.1.
DR   RefSeq; WP_010725310.1; NC_000117.1.
DR   AlphaFoldDB; O84713; -.
DR   SMR; O84713; -.
DR   STRING; 813.O172_03905; -.
DR   EnsemblBacteria; AAC68302; AAC68302; CT_707.
DR   GeneID; 884496; -.
DR   KEGG; ctr:CT_707; -.
DR   PATRIC; fig|272561.5.peg.778; -.
DR   HOGENOM; CLU_065756_0_0_0; -.
DR   InParanoid; O84713; -.
DR   OMA; YTIEGFR; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0051083; P:'de novo' cotranslational protein folding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0061077; P:chaperone-mediated protein folding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0043335; P:protein unfolding; IBA:GO_Central.
DR   Gene3D; 1.10.3120.10; -; 1.
DR   Gene3D; 3.10.50.40; -; 1.
DR   Gene3D; 3.30.70.1050; -; 1.
DR   HAMAP; MF_00303; Trigger_factor_Tig; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR005215; Trig_fac.
DR   InterPro; IPR008880; Trigger_fac_C.
DR   InterPro; IPR037041; Trigger_fac_C_sf.
DR   InterPro; IPR008881; Trigger_fac_ribosome-bd_bac.
DR   InterPro; IPR036611; Trigger_fac_ribosome-bd_sf.
DR   InterPro; IPR027304; Trigger_fact/SurA_dom_sf.
DR   PANTHER; PTHR30560; PTHR30560; 1.
DR   Pfam; PF05698; Trigger_C; 1.
DR   Pfam; PF05697; Trigger_N; 1.
DR   PIRSF; PIRSF003095; Trigger_factor; 1.
DR   SUPFAM; SSF102735; SSF102735; 1.
DR   SUPFAM; SSF109998; SSF109998; 1.
DR   TIGRFAMs; TIGR00115; tig; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chaperone; Cytoplasm; Isomerase;
KW   Reference proteome; Rotamase.
FT   CHAIN           1..442
FT                   /note="Trigger factor"
FT                   /id="PRO_0000179335"
FT   DOMAIN          176..259
FT                   /note="PPIase FKBP-type"
SQ   SEQUENCE   442 AA;  50101 MW;  F3EED2D8F1CCE313 CRC64;
     MSSRDFSNDL FSINIEENAG CVVSAKVQAN PLVTQKCHKE ALKTVKKNVV LPGFRKGKAP
     DNIVESRYST QMEQELRRLF LRASFEALSQ MCDRKPLSPK AVRSSAIDTC NPVNGGSVSF
     LYEAFPVIPS LPWEQLSLPD PEPVKEISEE DLENGLKNVA YFFATKTPVT RPSQEGDFIS
     LSLYVSKRGD ENSTPVAIFE NKYFKISEED MTDSFKARFL NVSTGHRVEE EIGSEDIQSF
     LNGDLLTFTV NAVIEISSPE MDDEKARQLQ AESLEDLKKK LRIQLENQAK EAQHQKRFSD
     AEDALAQLID FDLPESLLQE REELLSREKL LNARLVKYCS DSELEEQKQA LLEEAKADAR
     KAVKLLFLTQ KVFSEKGLSI SREELQYMMD VCSRERFGGY PPKDISNEMI QELVLVARDR
     LTYRKAIEAI SSEKKDLEVV PS