BSD2_SCHPO
ID BSD2_SCHPO Reviewed; 277 AA.
AC Q9P3T9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable metal homeostasis protein bsd1;
GN Name=bsd1; Synonyms=bsd2 {ECO:0000250|UniProtKB:P38356};
GN ORFNames=SPAC328.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB96002.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for homeostasis of heavy metal ions such as cadmium,
CC cobalt and copper. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P38356}. Vacuole {ECO:0000250|UniProtKB:P38356}.
CC Membrane {ECO:0000250|UniProtKB:P38356}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P38356}.
CC -!- SIMILARITY: Belongs to the BSD2 family. {ECO:0000255}.
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DR EMBL; CU329670; CAB96002.1; -; Genomic_DNA.
DR RefSeq; NP_594209.1; NM_001019632.2.
DR AlphaFoldDB; Q9P3T9; -.
DR SMR; Q9P3T9; -.
DR BioGRID; 279635; 1.
DR STRING; 4896.SPAC328.07c.1; -.
DR iPTMnet; Q9P3T9; -.
DR MaxQB; Q9P3T9; -.
DR PaxDb; Q9P3T9; -.
DR PRIDE; Q9P3T9; -.
DR EnsemblFungi; SPAC328.07c.1; SPAC328.07c.1:pep; SPAC328.07c.
DR GeneID; 2543206; -.
DR KEGG; spo:SPAC328.07c; -.
DR PomBase; SPAC328.07c; bsd1.
DR VEuPathDB; FungiDB:SPAC328.07c; -.
DR eggNOG; KOG4812; Eukaryota.
DR HOGENOM; CLU_041193_3_0_1; -.
DR InParanoid; Q9P3T9; -.
DR OMA; PYWDTTM; -.
DR PhylomeDB; Q9P3T9; -.
DR PRO; PR:Q9P3T9; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISO:PomBase.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISO:PomBase.
DR InterPro; IPR019325; NEDD4/Bsd2.
DR PANTHER; PTHR13396; PTHR13396; 1.
DR Pfam; PF10176; DUF2370; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Stress response;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..277
FT /note="Probable metal homeostasis protein bsd1"
FT /id="PRO_0000364024"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 30564 MW; 3DCC0B4E4E7FAC49 CRC64;
MSTNSNQNSI HTPIPEFPEN RSTNRSELAA AFEPPDDDVE YSETAPLYSS ARASIEGEEA
FYQHLSTPDP GNDSGHVRSS NDRIPSTSSN HADGHHVDSV FSNLSAKPTV ESNTEELEEE
PPSYEQAAAD TAPPYWDTTM VIPDYGSNEI YIDGMSVGTG FSFVWSACVA ILFPFVGFLV
TYVLSTTHLG RYGAQIGLSL TLFQRGYIMI SESGMENNDD QYNYDELPHQ KLIGSILIII
GWCLVLVDTF GFIRIRRMKN AISRTDSPGE TSPEEVV
