BSG2_DROME
ID BSG2_DROME Reviewed; 820 AA.
AC P11929; Q8IPK7;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Blastoderm-specific protein 25D;
GN Name=Bsg25D; ORFNames=CG14025;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3104878; DOI=10.1093/nar/15.5.2309;
RA Boyer P.D., Mahoney P.A., Lengyel J.A.;
RT "Molecular characterization of bsg25D: a blastoderm-specific locus of
RT Drosophila melanogaster.";
RL Nucleic Acids Res. 15:2309-2325(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95; SER-99; SER-100; SER-105;
RP SER-133; THR-136; SER-586; SER-693 AND SER-706, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- DEVELOPMENTAL STAGE: Blastoderm specific.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA28582.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA28582.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X04896; CAA28582.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014134; AAN10537.3; -; Genomic_DNA.
DR PIR; A26572; A26572.
DR RefSeq; NP_476916.4; NM_057568.6.
DR AlphaFoldDB; P11929; -.
DR SMR; P11929; -.
DR BioGRID; 59928; 27.
DR IntAct; P11929; 2.
DR STRING; 7227.FBpp0302745; -.
DR iPTMnet; P11929; -.
DR PaxDb; P11929; -.
DR DNASU; 33757; -.
DR EnsemblMetazoa; FBtr0342939; FBpp0309716; FBgn0000228.
DR GeneID; 33757; -.
DR KEGG; dme:Dmel_CG14025; -.
DR CTD; 33757; -.
DR FlyBase; FBgn0000228; Bsg25D.
DR VEuPathDB; VectorBase:FBgn0000228; -.
DR eggNOG; ENOG502R2VA; Eukaryota.
DR GeneTree; ENSGT00660000095541; -.
DR InParanoid; P11929; -.
DR OMA; DYPPRKE; -.
DR SignaLink; P11929; -.
DR BioGRID-ORCS; 33757; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 33757; -.
DR PRO; PR:P11929; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0000228; Expressed in cleaving embryo and 48 other tissues.
DR ExpressionAtlas; P11929; baseline and differential.
DR Genevisible; P11929; DM.
DR GO; GO:0005813; C:centrosome; IDA:FlyBase.
DR GO; GO:0000242; C:pericentriolar material; IDA:FlyBase.
DR GO; GO:0008017; F:microtubule binding; IDA:FlyBase.
DR GO; GO:0034454; P:microtubule anchoring at centrosome; IBA:GO_Central.
DR GO; GO:0034994; P:microtubule organizing center attachment site organization; IDA:FlyBase.
PE 1: Evidence at protein level;
KW Developmental protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..820
FT /note="Blastoderm-specific protein 25D"
FT /id="PRO_0000064997"
FT REGION 89..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 100
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 133
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 136
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 693
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 706
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 450
FT /note="T -> R (in Ref. 1; CAA28582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 820 AA; 92749 MW; 31013D2D96042F99 CRC64;
MEVSADPYEQ KLYQMFRSCE TQCGLLDEKS LLKLCSLLEL RDQGSALIAS LGGSHQLGVS
FGQFKEALLN FLGSEFDERS LVITDEPLNN TYIESPPESS DREVSPKLVV GTKKYGRRSR
PQQGIYELSV TDSDNTDEDQ LQQQQNQRSL NGCDELGVQV QRSSSQSDLP GSRRLRSVHT
SGSKLKRCAS LPARRKMNSN TTGATTSPTA AAKLKQLSIQ SQAQHSSSVE SLDTVTPQQL
ETISVHSIME AWELASIPNT RNLLHVLGFD EEEEVNLQQL TKALEEELRG IDGDHEQSNM
LRALAALQAT ELGNYRLAYR QQHEENLKLR ADNKAANQRV ALLAVEVDER HASLEDNSKK
QVQQLEQRHA SMVREITLRM TNDRDHWTSM TGKLEAQLKS LEQEEIRLRT ELELVRTENT
ELESEQQKAH IQITELLEQN IKLNQELAQT SSSIGGTPEH SPLRPRRHSE DKEEEMLQLM
EKLAALQMEN AQLRDKTDEL TIEIESLNVE LIRSKTKAKK QEKQEKQEDQ ESAATATKRR
GDSPSKTHLT EESPRLGKQR KCTEGEQSDA SNSGDWLALN SELQRSQSQD EELTSLRQRV
AELEEELKAA KEGRSLTPES RSKELETSLE QMQRAYEDCE DYWQTKLSEE RQLFEKERQI
YEDEQHESDK KFTELMEKVR EYEEQFSKDG RLSPIDERDM LEQQYSELEA EAAQLRSSSI
QMLEEKAQEI SSLQSEIEDL RQRLGESVEI LTGACELTSE SVAQLSAEAG KSPASSPISY
LWLQSTIQEP AKSLADSKDE ATASAIELLG GSPSHKTASR
