ID   BSHC_ALKHC              Reviewed;         538 AA.
AC   Q9K9R8;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=BH2577;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; BA000004; BAB06296.1; -; Genomic_DNA.
DR   PIR; A83972; A83972.
DR   RefSeq; WP_010898728.1; NC_002570.2.
DR   AlphaFoldDB; Q9K9R8; -.
DR   SMR; Q9K9R8; -.
DR   STRING; 272558.10175198; -.
DR   PRIDE; Q9K9R8; -.
DR   EnsemblBacteria; BAB06296; BAB06296; BAB06296.
DR   KEGG; bha:BH2577; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Ligase; Reference proteome.
FT   CHAIN           1..538
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378218"
SQ   SEQUENCE   538 AA;  62270 MW;  470E31DE2FC0C507 CRC64;
     MIVEELKLLP SSKAAKDYLN NQNDMLSFFD YNIHQPTVFQ QRLSDLQEQP YDRDALSKAL
     LSYQKRFAFH DKAAQQVEKL KDPRSVVVIG GQQAGLLTGP LYTIYKAVTI VLLAREQERA
     LGVPVVPVFW IAGEDHDLDE INAVPIEKNG RWRSHRIEEK RKRIASEAGL NKETLAKWLA
     TVFRSLPETE HTLPLYERVK TLAGRSNTYT DFFAELLLYL FRDEGLVVFD SGDPSFRTLE
     KSCFHMLIQK TKNVQGAFAH QVKKLEQAGY GRPIITEETN AHLFYVEEGS RYRIDYTGEN
     YELNGKNQTF SREELLEHLT LHPERFSNNV VTRPVMQDAL FPVLAFVAGP GEISYWATLK
     RVFHECGMKM SPVVPRISAT CVPSAVQKWF AEKQYSYEEA IAHGLEKEKE GWLEEQTPWP
     IDQVVEEAIT QIRHSHKPIK DLAEQIGETP GKLANKNWSI IESQLRFMER RMKRHVRERF
     EHELSKFDEA ERWLKPNGLL QERHDHVIQL LNIVGDDFIP RLISMNINKM GVHYLVKL