ID   BSHC_ANOFW              Reviewed;         536 AA.
AC   B7GGJ1;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=Aflv_1839;
OS   Anoxybacillus flavithermus (strain DSM 21510 / WK1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Anoxybacillus.
OX   NCBI_TaxID=491915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21510 / WK1;
RX   PubMed=19014707; DOI=10.1186/gb-2008-9-11-r161;
RA   Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A.,
RA   Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V.,
RA   Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.;
RT   "Encapsulated in silica: genome, proteome and physiology of the
RT   thermophilic bacterium Anoxybacillus flavithermus WK1.";
RL   Genome Biol. 9:R161.1-R161.16(2008).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; CP000922; ACJ34200.1; -; Genomic_DNA.
DR   RefSeq; WP_012575398.1; NC_011567.1.
DR   AlphaFoldDB; B7GGJ1; -.
DR   SMR; B7GGJ1; -.
DR   STRING; 491915.Aflv_1839; -.
DR   EnsemblBacteria; ACJ34200; ACJ34200; Aflv_1839.
DR   KEGG; afl:Aflv_1839; -.
DR   PATRIC; fig|491915.6.peg.1891; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000000742; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Ligase; Reference proteome.
FT   CHAIN           1..536
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378205"
SQ   SEQUENCE   536 AA;  62890 MW;  306ECDA0F4D694DA CRC64;
     MEVIELSLPA TNRLATEYIE GTFPVHEAFH PCSFKERLHE LHKRTYARDA LVHHLLAYHK
     QFQASEETMA NIEKLRHRES VVVIGGQQAG LLTGPLYTIY KIISIITLAK QQEQQLRVPV
     VPVFWMASED HDMAEINYVH VAQRGKVKKY VYSPLAKEKR MAAHIELDAD ALKQWIDDIF
     KTFGETNVTN ELRTYIYECM ATSKTVADFF ATIVLKLFAK EGIVIVDAAH PHLRAIEREW
     FMTLAHEHEA ITTALQTQQR HLAQLGYEQA IDVSPMCAHL FYDDGQRRLL YYDDAQHCFY
     TKDGVYRFTP NELRQRIESE PQSFSNNVVT RPLMQEWLFP TLAFIAGPGE IAYWAELKRV
     FEHFHWHMPP IVPRLSLTLV ERHIAADLAD VHMTVAEALT NGTKQALEEW MRNNQPVAFD
     ETFHEAKKQM AYIHEQLRQL GMQVDPHLEG IMLKNAERVE TQIDYLQQLI TRRMLQKHDV
     HVRKYERIEL SLRPNNMPQE RVWNVLYYMN RYGLDFVDRL LHVDYRWNGM HKIVYL