ID   TILB_MACFA              Reviewed;         466 AA.
AC   Q4R3F0;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protein tilB homolog;
DE   AltName: Full=Leucine-rich repeat-containing protein 6;
GN   Name=LRCC6; ORFNames=QtsA-17365;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in dynein arm assembly, hence essential for
CC       proper axoneme building for cilia motility. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via CS domain) with ZMYND10 (via C-terminus).
CC       {ECO:0000250|UniProtKB:Q86X45}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, cilium
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tilB family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB179316; BAE02367.1; -; mRNA.
DR   AlphaFoldDB; Q4R3F0; -.
DR   SMR; Q4R3F0; -.
DR   STRING; 9541.XP_005564149.1; -.
DR   PRIDE; Q4R3F0; -.
DR   eggNOG; KOG0531; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR   SMART; SM00446; LRRcap; 1.
DR   PROSITE; PS51203; CS; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Leucine-rich repeat;
KW   Reference proteome; Repeat.
FT   CHAIN           1..466
FT                   /note="Protein tilB homolog"
FT                   /id="PRO_0000084497"
FT   REPEAT          22..43
FT                   /note="LRR 1"
FT   REPEAT          45..66
FT                   /note="LRR 2"
FT   REPEAT          67..88
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          123..161
FT                   /note="LRRCT"
FT   DOMAIN          301..396
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   REGION          185..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          178..204
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   466 AA;  54161 MW;  48FB8CC2FFC77B66 CRC64;
     MGWITEDLIR RNAEHNDCVI FSLEELSLHQ QEIERLEHID KWCRDLKILY LQNNLIGKIE
     NVSKLKKLEY LNLALNNIEK IENLEGCEEL AKLDLTVNFI GELSSIKTLK HNIHLKELFL
     MGNPCAFFDH YREFVVATLP QLKWLDGKGI EPSERIKALQ EYSIIEPQIR EQEKDHCLKR
     AKLKEEAQRK HQEEDKNEDK RSNAGFDGRW YTDINATLSS LESKDHLQAP DTEEHNTKKL
     DNSEDDLEFW NKPCLFTPES RLETLRHMEK QRKNQEKLSE RKKKVKPPRT LITEDGKALN
     VNEPKIDFSL KDNEKQIILD LAVYRYMDTS LINVDVQPTY VRVMIKGKPF QLVLPAEVKP
     DSSSAKRSQT TGHLVICMPK VGEVITGGQR AFTSVKTTSD RSREHINTRS KHMEKLEVDP
     SKHSFPDVTN IVQGKKHTPR RRPEPKIIPS EEDPTFEDNP EVPPLI