ID   BSHC_GEOKA              Reviewed;         542 AA.
AC   Q5L0Y5;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=GK1110;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; BA000043; BAD75395.1; -; Genomic_DNA.
DR   RefSeq; WP_011230610.1; NC_006510.1.
DR   AlphaFoldDB; Q5L0Y5; -.
DR   SMR; Q5L0Y5; -.
DR   STRING; 235909.GK1110; -.
DR   EnsemblBacteria; BAD75395; BAD75395; GK1110.
DR   KEGG; gka:GK1110; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase; Reference proteome.
FT   CHAIN           1..542
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378238"
FT   COILED          458..487
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   542 AA;  61270 MW;  973104E6323830FC CRC64;
     MEVREIPLPA ATKLAADYIT GAFPAESGFA YAQADDEAFC RRLAYLQGRT YDREGLADYL
     RAYHRRFSAS VATMANIEKL RNERSVVIVG GQQAGLLTGP LYTIYKIITI IQLAKEQERK
     LGVPVVPLFW IAGEDHDIAE IDHVYVVEEG EVKKAAYPHK TNEKRMAADV LLDRMAAKEW
     IERVVKTYGE TDVTNELLFF LSSCLDEART FVDFFAAIVL RLFADHGLVV LNAGDAAVRP
     LERRFFAALI ERHRDVTAAV LAQQEALRTL GYAPLIEIGR DAANLFYYDG RERSLLQYDE
     ERGLFHNKAG TLVWTREELL ELAETNPARL SNNVVTRPLM QEHLLPTLAF VAGPGEIAYW
     AELKEAFPLF DLEMPPVVPR LQATIVSRSL QTDLSDIGLE VADVLTGRLD EAKREWREAT
     AQAPLASAFA KAKADIDAAH RPLRELGVAI DRGLEGLVAK NAAILQAQIE FLQHALERAL
     LRKHETEWRK FWRIETSLRP NGALQERVWN VFYYINRYGF DFVEKLLAIR SPGNGMHKIV
     YM