ID   BSHC_GEOTN              Reviewed;         542 AA.
AC   A4ILZ9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=GTNG_0975;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABO66353.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000557; ABO66353.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_008878697.1; NC_009328.1.
DR   AlphaFoldDB; A4ILZ9; -.
DR   SMR; A4ILZ9; -.
DR   STRING; 420246.GTNG_0975; -.
DR   EnsemblBacteria; ABO66353; ABO66353; GTNG_0975.
DR   KEGG; gtn:GTNG_0975; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase.
FT   CHAIN           1..542
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378239"
FT   COILED          458..487
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   542 AA;  60764 MW;  63297773469528F2 CRC64;
     MEVREVPLPA TTKLAADYIT GAFPAEKGFG YARTDDEAFR RRLIHLQTRT YDRHGLADYL
     QAYHRRFSAS AATMNNIDKL RDENSVVIVG GQQAGLLTGP LYTIYKIITI IRLAKEQEQK
     LGVPVVPLFW IAGEDHDIAE VDHVYVVEDG EVKKVVYPHK LKEKQMAADV PLDRQLADAW
     IERVVKTYGE TDVTNELLSF LAACLDDSHT FVDFFAAIVL RLFADDGLVV LNAGDASVRP
     LERRFFAALI DRHRDVTSAV LAQQEALRAL GYAPLIEIAP NAANLFYYDG RERSLLHYDE
     ESGLFRNKTG SVALTKQQLL ELAEAKPACL SNNVVTRPLM QEYLLPTLAF IAGPGEIAYW
     AELKEVFALF GMEMPPVVPR LQATLVSRSL QTDLVDIGLE AADVLSGRLE AVKQQWLKAT
     AEAPLTEAFA KAKADIEAAH RPLRELGVAI DRGLEGLVAK NAAIIQAQIE FLQQTLERAL
     LSKHEVEWRK FWRVETSLRP NGAPQERVWN VFYYVNRYGF DFVEKLSAIS NPGNGMHKIV
     YI