ID   BSHC_HELMI              Reviewed;         547 AA.
AC   B0TAU6;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=Helmi_24320;
GN   ORFNames=HM1_2509;
OS   Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Heliobacteriaceae;
OC   Heliomicrobium.
OX   NCBI_TaxID=498761;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51547 / Ice1;
RX   PubMed=18441057; DOI=10.1128/jb.00299-08;
RA   Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA   Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA   Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA   Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT   "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT   of the Firmicutes containing the simplest photosynthetic apparatus.";
RL   J. Bacteriol. 190:4687-4696(2008).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; CP000930; ABZ85057.1; -; Genomic_DNA.
DR   RefSeq; WP_012283553.1; NC_010337.2.
DR   AlphaFoldDB; B0TAU6; -.
DR   SMR; B0TAU6; -.
DR   STRING; 498761.HM1_2509; -.
DR   EnsemblBacteria; ABZ85057; ABZ85057; HM1_2509.
DR   KEGG; hmo:HM1_2509; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   Proteomes; UP000008550; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase; Reference proteome.
FT   CHAIN           1..547
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378241"
FT   COILED          462..484
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   547 AA;  61944 MW;  E7FEE0B61381FCD9 CRC64;
     MSFERTGSIF SGLAGAYVQR EAHVVSLFPY AFPDENALAL RARRMTATDS YPRSELSSLL
     EGYQRRLADL AGLEGSSNRA ADQARRLAEA NSLAVVTGQQ AGLFTGPLYT IYKAVTCINL
     AKRLEAKTGQ PVIPVFWVAS EDHDFEEISH IKLLQGEKTV VITMTSRPDE DRFAIGHRTL
     PEDLAVTLES FLSHLPQSEH RLPWEETWHR LLTGPTGPHE HFAALLHKLL GPYGLVILDP
     LLSGLKQLPR CASFFASVLE NEVSLREGLS RGVEQIRRLG YTPQVEKGPE ETSLFYFHQG
     RRLAILRDGR GYRLRGAEIT FSRDELLDLA QRQPDLFSTN VVTRPLLQDQ LLPTTAYVAG
     PGEIAYFAAY RDVYRAMGME MPPIVPRLSV TIIEGFVDKL LERYALSFAD VPAGLEGRLR
     EELAAQDELG IGALFEELES QVRAAYLPAV ERIARWDRQM GNLAEENLDR VIAQARFLRQ
     KVEHRHRQRC QDKRNHFRKV ELHLWPGAPQ ERVYNIFPYL LKYGSSLIET LLEAPVEWLD
     SHCLFRC