ID   BSHC_LYSSC              Reviewed;         538 AA.
AC   B1HPX8;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=Bsph_1424;
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41;
RX   PubMed=18296527; DOI=10.1128/jb.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; CP000817; ACA39030.1; -; Genomic_DNA.
DR   RefSeq; WP_012293150.1; NC_010382.1.
DR   AlphaFoldDB; B1HPX8; -.
DR   SMR; B1HPX8; -.
DR   EnsemblBacteria; ACA39030; ACA39030; Bsph_1424.
DR   KEGG; lsp:Bsph_1424; -.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase.
FT   CHAIN           1..538
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378242"
FT   COILED          419..445
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   538 AA;  62732 MW;  E4C24398836C0FFC CRC64;
     MKLESIQVPI KNNVLADYWS PNTAIHQFFE YEFNDQAFEK RAKHLAQHAR DQKELTAIIR
     QFMEPLGLSQ KANEHLQQLE QGAMVIIGGQ QAGILTGPLY SVHKAISVIV LAKEQSVKLQ
     RSVVPVFWIA GEDHDLEEIN HTYTVHGELL KKRAYSERSR RKTMASATML NKESMTQFIH
     TVVRDIGETE YTEALIKQLV DVLNESETFT DFFARLMNQL FKDEGLLLID AADYNFRQYE
     STNFTHIIQH SEEIARVVTE KEEQLERTGY GKPILATREA ANLFYVEDGE RHLLERKNDL
     FINLAANLKF TREELLEIAE KYPERLSNNV VSRPLMQEMT FPVLAFVGGP GELAYWATLK
     SAFSVLDLQM PIFAPRLHMT IVTRHVEQLL REHQLSVTDV WNGKALEMKE RFIHDVQDIE
     AKRQIQAMEQ LLAEKYSELA SYLEEQHLTL DKILVKNQEN HAKQFDYLQQ KIEQTVLDKH
     ETTIRKFTTL QNELYPNEGF QERTYNPYQY FNEFGPMLIA EMLKQNYSIG KHHYLLYL