ID   BSHC_NATTJ              Reviewed;         544 AA.
AC   B2A252;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=Nther_1274;
OS   Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 /
OS   JW/NM-WN-LF).
OC   Bacteria; Firmicutes; Clostridia; Natranaerobiales; Natranaerobiaceae;
OC   Natranaerobius.
OX   NCBI_TaxID=457570;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.;
RT   "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-
RT   LF.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; CP001034; ACB84857.1; -; Genomic_DNA.
DR   RefSeq; WP_012447732.1; NC_010718.1.
DR   AlphaFoldDB; B2A252; -.
DR   SMR; B2A252; -.
DR   STRING; 457570.Nther_1274; -.
DR   EnsemblBacteria; ACB84857; ACB84857; Nther_1274.
DR   KEGG; nth:Nther_1274; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000001683; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase; Reference proteome.
FT   CHAIN           1..544
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378244"
FT   COILED          431..463
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   544 AA;  63843 MW;  48764CF31FF05D92 CRC64;
     MFQNEVTFNE DMGSQVYLDY LYNFDPLKDF FELSPWQESS FEKQAKKLQE REANRRTFRN
     QLTLGLHNYH KKFTDNPKVY NTIELLNDPE TMTVVTGQQP GIMTGPLFAI YKIITAIKLS
     KKLSKNLDAN VIPIFWICSD DHDFQEVNWL KTVDHKGEQL LYEIHDDKEG FSIGDRDIKH
     KSQDLLDKLA QQLQDSPYYD KWMTLFSKTL EQSKTLADWT AAIILELFGN EGVLVIDPMK
     PVFRQLSKPI FSKALDLGEG LHNSIDSQTE KLNNRGYSGQ VDLRVNHSGL FYYYQGIRSP
     LTVEGDQFLL ANLGIEKSKE DLVRELESDP AKFSPNVTLW PVLQDFLLPS LAYVAGPGEI
     SYFAQLKQIY EQFEIGMPVI YPRESYLLLE SDVKSILEKY QIGPENIFYD WPTTRKRVFR
     ELAPINTEKV LNDTCRTIKE EHEKFIQELS RLDEKIYDFE EKNFHLIYRQ LYYLKEKGDQ
     YFRRQQLQAQ RDLDYSKIKI YPLDKLQERE YNIGEFLCKY DSSVLKKLLK TPLNPQKISV
     VDLE