TIM14_CAEEL
ID TIM14_CAEEL Reviewed; 112 AA.
AC P91454;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit TIM14;
DE AltName: Full=DnaJ homolog subfamily C member 21;
GN Name=dnj-21; Synonyms=tim-14; ORFNames=T19B4.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable component of the PAM complex, a complex required for
CC the translocation of transit peptide-containing proteins from the inner
CC membrane into the mitochondrial matrix in an ATP-dependent manner. May
CC act as a co-chaperone that stimulate the ATP-dependent activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Probable component of the PAM complex at least composed of a
CC mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14/dnj-21.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TIM14 family. {ECO:0000305}.
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DR EMBL; FO080338; CCD62976.1; -; Genomic_DNA.
DR PIR; T25890; T25890.
DR RefSeq; NP_491662.1; NM_059261.4.
DR AlphaFoldDB; P91454; -.
DR SMR; P91454; -.
DR BioGRID; 37688; 3.
DR STRING; 6239.T19B4.4; -.
DR EPD; P91454; -.
DR PaxDb; P91454; -.
DR PeptideAtlas; P91454; -.
DR EnsemblMetazoa; T19B4.4.1; T19B4.4.1; WBGene00001039.
DR GeneID; 172231; -.
DR KEGG; cel:CELE_T19B4.4; -.
DR UCSC; T19B4.4; c. elegans.
DR CTD; 172231; -.
DR WormBase; T19B4.4; CE13742; WBGene00001039; dnj-21.
DR eggNOG; KOG0723; Eukaryota.
DR GeneTree; ENSGT00940000171836; -.
DR HOGENOM; CLU_017633_13_3_1; -.
DR InParanoid; P91454; -.
DR OMA; GFQQTMT; -.
DR OrthoDB; 1600166at2759; -.
DR PhylomeDB; P91454; -.
DR PRO; PR:P91454; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001039; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR GO; GO:0001405; C:PAM complex, Tim23 associated import motor; IBA:GO_Central.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 3: Inferred from homology;
KW Chaperone; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..112
FT /note="Mitochondrial import inner membrane translocase
FT subunit TIM14"
FT /id="PRO_0000071105"
FT TOPO_DOM 1..3
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..112
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT DOMAIN 59..112
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ SEQUENCE 112 AA; 11731 MW; 44468EDE4985F00E CRC64;
MTGGLIVAGL GLAAVGFGAR YVLRNQALIK KGMEAIPVAG GAFSNYYRGG FDQKMSRAEA
AKILGVAPSA KPAKIKEAHK KVMIVNHPDR GGSPYLAAKI NEAKDLMESS KS
