ID   TIM16_CAEBR             Reviewed;         138 AA.
AC   Q60RS2; A8XZL5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit tim-16;
GN   ORFNames=CBG21207 {ECO:0000312|WormBase:CBG21207};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Regulates ATP-dependent protein translocation into the
CC       mitochondrial matrix. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the PAM complex at least composed of a
CC       mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14.
CC       Associates with the TIM23 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- DOMAIN: The J-like region, although related to the J domain does not
CC       have co-chaperone activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TIM16/PAM16 family. {ECO:0000305}.
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DR   EMBL; HE600921; CAP38014.3; -; Genomic_DNA.
DR   RefSeq; XP_002642811.1; XM_002642765.1.
DR   AlphaFoldDB; Q60RS2; -.
DR   SMR; Q60RS2; -.
DR   STRING; 6238.CBG21207; -.
DR   EnsemblMetazoa; CBG21207.1; CBG21207.1; WBGene00040050.
DR   GeneID; 8584805; -.
DR   KEGG; cbr:CBG_21207; -.
DR   CTD; 8584805; -.
DR   WormBase; CBG21207; CBP11703; WBGene00040050; -.
DR   eggNOG; KOG3442; Eukaryota.
DR   HOGENOM; CLU_101461_3_0_1; -.
DR   InParanoid; Q60RS2; -.
DR   OrthoDB; 1640138at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR005341; Tim16.
DR   PANTHER; PTHR12388; PTHR12388; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..138
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit tim-16"
FT                   /id="PRO_0000214085"
FT   REGION          32..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..119
FT                   /note="J-like"
FT   REGION          118..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   138 AA;  15532 MW;  AD4AE6C9F4B9FDA3 CRC64;
     MPWRTALKVA LAAGEAVTKA LTRAVRDEIR QTQQAAARHA AATGQSPSET KENANANAKL
     GISLEESLQI LNVKTPLNRE DVEKHYEHLF AINDKAKGGT FYLQSKVYRA KERIDEELSR
     LEQKSEENKE QQKENSKE