ID   TIM16_CAEEL             Reviewed;         136 AA.
AC   O62250;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit tim-16;
GN   ORFNames=F45G2.8 {ECO:0000312|WormBase:F45G2.8};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Regulates ATP-dependent protein translocation into the
CC       mitochondrial matrix. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the PAM complex at least composed of a
CC       mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and dnj-21/tim-14.
CC       Associates with the TIM23 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- DOMAIN: The J-like region, although related to the J domain does not
CC       have co-chaperone activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TIM16/PAM16 family. {ECO:0000305}.
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DR   EMBL; Z93382; CAB07617.1; -; Genomic_DNA.
DR   PIR; T22240; T22240.
DR   RefSeq; NP_499775.1; NM_067374.5.
DR   AlphaFoldDB; O62250; -.
DR   SMR; O62250; -.
DR   BioGRID; 41938; 3.
DR   STRING; 6239.F45G2.8; -.
DR   EPD; O62250; -.
DR   PaxDb; O62250; -.
DR   PeptideAtlas; O62250; -.
DR   EnsemblMetazoa; F45G2.8.1; F45G2.8.1; WBGene00009734.
DR   GeneID; 176769; -.
DR   KEGG; cel:CELE_F45G2.8; -.
DR   UCSC; F45G2.8.2; c. elegans.
DR   CTD; 176769; -.
DR   WormBase; F45G2.8; CE16051; WBGene00009734; -.
DR   eggNOG; KOG3442; Eukaryota.
DR   GeneTree; ENSGT00390000012037; -.
DR   HOGENOM; CLU_101461_3_0_1; -.
DR   InParanoid; O62250; -.
DR   OMA; RMFKIND; -.
DR   OrthoDB; 1640138at2759; -.
DR   PhylomeDB; O62250; -.
DR   PRO; PR:O62250; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00009734; Expressed in larva and 4 other tissues.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR005341; Tim16.
DR   PANTHER; PTHR12388; PTHR12388; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..136
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit tim-16"
FT                   /id="PRO_0000214086"
FT   REGION          32..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..119
FT                   /note="J-like"
FT   COMPBIAS        35..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   136 AA;  15276 MW;  27B52F93A7743962 CRC64;
     MPWRTALKVA LAAGEAVAKA LTRAVRDEIK QTQQAAARHA ASTGQSASET RENANSNAKL
     GISLEESLQI LNVKTPLNRE EVEKHYEHLF NINDKSKGGT LYLQSKVFRA KERIDEEFGR
     IELKEEKKKE ENAKTE