ID   TIM16_RAT               Reviewed;         124 AA.
AC   Q6EIX2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM16;
DE   AltName: Full=Mitochondria-associated granulocyte macrophage CSF-signaling molecule;
DE   AltName: Full=Presequence translocated-associated motor subunit PAM16;
GN   Name=Magmas-ps1; Synonyms=Magmas, Pam16, Tim16, Timm16;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15984936;
RA   Peng J., Huang C.-H., Short M.K., Jubinsky P.T.;
RT   "Magmas gene structure and evolution.";
RL   In Silico Biol. 5:251-263(2005).
CC   -!- FUNCTION: Regulates ATP-dependent protein translocation into the
CC       mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin
CC       ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the PAM complex at least composed of a
CC       mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and
CC       TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly
CC       interacts with DNAJC15; this interaction counteracts DNAJC15-dependent
CC       stimulation of HSPA9 ATPase activity (By similarity). Associates with
CC       the TIM23 complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- DOMAIN: The J-like region, although related to the J domain does not
CC       have co-chaperone activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TIM16/PAM16 family. {ECO:0000305}.
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DR   EMBL; AY320044; AAQ86805.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6EIX2; -.
DR   SMR; Q6EIX2; -.
DR   jPOST; Q6EIX2; -.
DR   PRIDE; Q6EIX2; -.
DR   RGD; 1564452; Magmas-ps1.
DR   eggNOG; KOG3442; Eukaryota.
DR   InParanoid; Q6EIX2; -.
DR   PhylomeDB; Q6EIX2; -.
DR   TreeFam; TF315134; -.
DR   PRO; PR:Q6EIX2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0001503; P:ossification; ISS:UniProtKB.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR005341; Tim16.
DR   PANTHER; PTHR12388; PTHR12388; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..124
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit TIM16"
FT                   /id="PRO_0000214080"
FT   REGION          58..109
FT                   /note="J-like"
FT   MOD_RES         69
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQV1"
SQ   SEQUENCE   124 AA;  13730 MW;  8769EBC5890FF1A5 CRC64;
     MAKYLTQIIV MGVQVVGRDF AKALRQEFAA SQAAADARGH AGHQSAAASN LSGLSLQEAQ
     QILNISKLSP EEVQNYEHLF KVNDKSVGDS FYLQSKVVRA KERLDEELQI QAQEDREKGQ
     MPKT