ID   TIM17_NEUCR             Reviewed;         155 AA.
AC   P59670; Q7S5Y3;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   09-MAY-2003, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit tim17;
GN   Name=tim17; ORFNames=NCU05623;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Nargang F.E., Tan W.-L., Prokisch H.;
RT   "The Neurospora crassa TIM23 translocase of mitochondrial inner membrane.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TIM23 complex, at least composed of tim23,
CC       tim17, tim50 and tim21. The complex interacts with the tim44 component
CC       of the PAM complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; AY212506; AAO72334.1; -; mRNA.
DR   EMBL; CM002241; EAA30931.1; -; Genomic_DNA.
DR   RefSeq; XP_960167.1; XM_955074.2.
DR   AlphaFoldDB; P59670; -.
DR   STRING; 5141.EFNCRP00000005528; -.
DR   EnsemblFungi; EAA30931; EAA30931; NCU05623.
DR   GeneID; 3876316; -.
DR   KEGG; ncr:NCU05623; -.
DR   VEuPathDB; FungiDB:NCU05623; -.
DR   HOGENOM; CLU_087811_3_0_1; -.
DR   InParanoid; P59670; -.
DR   OMA; CPWVILS; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..155
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit tim17"
FT                   /id="PRO_0000210294"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DISULFID        8..75
FT                   /evidence="ECO:0000250|UniProtKB:P39515"
SQ   SEQUENCE   155 AA;  16184 MW;  78F48D2F3720E5FB CRC64;
     MDHTRDPCPW VILNDFGGAF AMGAIGGTIW HGIKGFRNSP YGERRIGAIT AIKMRAPALG
     GNFGVWGGLF STFDCAIKGL RNHKEDPWNS ILAGFFTGGA LAVRGGYKAA RNGAIGCAVL
     LAVIEGVGIG FQKMLAGATK LEAPAPPPSN EKVLA