ID   BSHC_STAAB              Reviewed;         537 AA.
AC   Q2YXE5;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=SAB1041;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; AJ938182; CAI80729.1; -; Genomic_DNA.
DR   RefSeq; WP_000340468.1; NC_007622.1.
DR   AlphaFoldDB; Q2YXE5; -.
DR   SMR; Q2YXE5; -.
DR   PRIDE; Q2YXE5; -.
DR   KEGG; sab:SAB1041; -.
DR   HOGENOM; CLU_022249_0_0_9; -.
DR   OMA; TTGHQLN; -.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase.
FT   CHAIN           1..537
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378252"
FT   COILED          422..450
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   537 AA;  62832 MW;  0804A96574949C1C CRC64;
     MDCKVVSLNE KDQFIPKIKS SDPVITGLFQ YDAAQQTSFE KRMSKENNGR EAALANVIRE
     YMSDLKLSSE QELNIQHLAN GSKVVIGGQQ AGLFGGPLYI FHKIFSIITL SKELTDTHKQ
     QVVPVFWIAG EDHDFDEVNH TFVYNENHGS LHKVKYHTME MPETTISRYY PDKAELKQTL
     KTMFIHMKET VHTQGLLEIC DRIIDQYDSW TDMFKALLHE TFKAYGVLFI DAQFEPLRKM
     EAPMFKKILK KHQLLDDAFR ATQQRTQNQG LKAMIQTDTN VHLFLHDENM RQLVSYDGKH
     FKLNKTDKTY VKEEIINIAE NQPELFSNNV VTRPLMEEWL FNTVAFIGGP SEIKYWAELK
     DVFELFDVEM PIVMPRLRIT YLNDRIEKIL SKYNIPLEKV LVDGVEGERS KFIRELASHQ
     FIEKVEGMIE QQRRLNQDLL DEVAGNQNNI NLVNKNNEIH IQQYDYLLKR YLLNIEREND
     ISMKQFREIQ ETLHPMGGLQ ERIWNPLQIL NDFGTDVFKP STYPPLSYTF DHIIIKP