TIM17_SCHPO
ID TIM17_SCHPO Reviewed; 164 AA.
AC P87130;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit tim17;
DE AltName: Full=Mitochondrial protein import protein 2;
GN Name=tim17; ORFNames=SPAC3A12.16c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane. {ECO:0000250}.
CC -!- SUBUNIT: Component of the TIM23 complex, at least composed of tim23,
CC tim17, tim50 and tim50. The complex interacts with the tim44 component
CC of the PAM complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB08744.1; -; Genomic_DNA.
DR PIR; T38684; T38684.
DR RefSeq; NP_593342.1; NM_001018774.2.
DR AlphaFoldDB; P87130; -.
DR SMR; P87130; -.
DR ComplexPortal; CPX-540; Mitochondrial inner membrane pre-sequence translocase complex.
DR STRING; 4896.SPAC3A12.16c.1; -.
DR MaxQB; P87130; -.
DR PaxDb; P87130; -.
DR EnsemblFungi; SPAC3A12.16c.1; SPAC3A12.16c.1:pep; SPAC3A12.16c.
DR GeneID; 2543163; -.
DR KEGG; spo:SPAC3A12.16c; -.
DR PomBase; SPAC3A12.16c; tim17.
DR VEuPathDB; FungiDB:SPAC3A12.16c; -.
DR eggNOG; KOG1652; Eukaryota.
DR HOGENOM; CLU_087811_3_0_1; -.
DR InParanoid; P87130; -.
DR OMA; CPWVILS; -.
DR PhylomeDB; P87130; -.
DR Reactome; R-SPO-1268020; Mitochondrial protein import.
DR PRO; PR:P87130; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0015450; F:protein-transporting ATPase activity; ISS:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:ComplexPortal.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; ISS:PomBase.
DR InterPro; IPR005678; Tim17.
DR TIGRFAMs; TIGR00980; 3a0801so1tim17; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..164
FT /note="Mitochondrial import inner membrane translocase
FT subunit tim17"
FT /id="PRO_0000210295"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DISULFID 11..78
FT /evidence="ECO:0000250|UniProtKB:P39515"
SQ SEQUENCE 164 AA; 16901 MW; 4826B4895F115BCF CRC64;
MASADHTRDP CPYVILNDFG AAFSMGTIGG AIWHSIKGWR NSPPGEKRIS AIAAAKTRAP
VLGGNFGVWG GLFSTFDCAV KGVRRKEDPW NAIIAGFFTG GALAVRGGWR ATRNGAIGCA
CILAVFEGLG IALGRMNAEY NRPVAPVIPD APASGSTSAA PAAV
