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TIM21_ARATH
ID   TIM21_ARATH             Reviewed;         269 AA.
AC   Q1G3L1;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Probable mitochondrial import inner membrane translocase subunit TIM21;
DE   AltName: Full=Protein SEGREGATION DISTORTION 3;
DE   Flags: Precursor;
GN   Name=TIM21; Synonyms=SD3; OrderedLocusNames=At4g00026; ORFNames=F6N15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Morosawa T.,
RA   Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K.,
RA   Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K.,
RA   Akiyama K., Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
RA   Hayashizaki Y., Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=22131050; DOI=10.1093/mp/ssr088;
RA   Hamasaki H., Yoshizumi T., Takahashi N., Higuchi M., Kuromori T., Imura Y.,
RA   Shimada H., Matsui M.;
RT   "SD3, an Arabidopsis thaliana homolog of TIM21, affects intracellular ATP
RT   levels and seedling development.";
RL   Mol. Plant 5:461-471(2012).
RN   [6]
RP   INTERACTION WITH TIM23-2 AND CYTOCHROME BC1 COMPLEX, SUBCELLULAR LOCATION,
RP   AND SUBUNIT.
RX   PubMed=22730406; DOI=10.1105/tpc.112.098731;
RA   Wang Y., Carrie C., Giraud E., Elhafez D., Narsai R., Duncan O., Whelan J.,
RA   Murcha M.W.;
RT   "Dual location of the mitochondrial preprotein transporters B14.7 and
RT   Tim23-2 in complex I and the TIM17:23 complex in Arabidopsis links
RT   mitochondrial activity and biogenesis.";
RL   Plant Cell 24:2675-2695(2012).
CC   -!- FUNCTION: May participate in the translocation of transit peptide-
CC       containing proteins across the mitochondrial inner membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the respiratory complex III. Interacts with TIM23-2
CC       and the cytochrome c1 and c2 subunits of complex III.
CC       {ECO:0000269|PubMed:22730406}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, sheath, flowers and buds.
CC       Lower expression in roots and stems. {ECO:0000269|PubMed:22131050}.
CC   -!- DISRUPTION PHENOTYPE: Strong lethality at the post-seedling stage.
CC       {ECO:0000269|PubMed:22131050}.
CC   -!- SIMILARITY: Belongs to the TIM21 family. {ECO:0000305}.
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DR   EMBL; AF069299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002687; AEE81815.1; -; Genomic_DNA.
DR   EMBL; DQ487573; ABF59236.1; -; mRNA.
DR   EMBL; AK228629; BAF00539.1; -; mRNA.
DR   RefSeq; NP_001031562.1; NM_001036485.4.
DR   AlphaFoldDB; Q1G3L1; -.
DR   SMR; Q1G3L1; -.
DR   BioGRID; 530772; 1.
DR   STRING; 3702.AT4G00026.1; -.
DR   iPTMnet; Q1G3L1; -.
DR   PaxDb; Q1G3L1; -.
DR   PRIDE; Q1G3L1; -.
DR   ProteomicsDB; 246426; -.
DR   EnsemblPlants; AT4G00026.1; AT4G00026.1; AT4G00026.
DR   GeneID; 3770411; -.
DR   Gramene; AT4G00026.1; AT4G00026.1; AT4G00026.
DR   KEGG; ath:AT4G00026; -.
DR   Araport; AT4G00026; -.
DR   TAIR; locus:1009023383; AT4G00026.
DR   eggNOG; KOG4836; Eukaryota.
DR   HOGENOM; CLU_069478_1_0_1; -.
DR   InParanoid; Q1G3L1; -.
DR   OMA; PIKGYGQ; -.
DR   OrthoDB; 1330321at2759; -.
DR   PhylomeDB; Q1G3L1; -.
DR   PRO; PR:Q1G3L1; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q1G3L1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0090351; P:seedling development; IMP:TAIR.
DR   Gene3D; 3.10.450.320; -; 1.
DR   InterPro; IPR013261; Tim21.
DR   InterPro; IPR038552; Tim21_IMS_sf.
DR   PANTHER; PTHR13032; PTHR13032; 1.
DR   Pfam; PF08294; TIM21; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..70
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           71..269
FT                   /note="Probable mitochondrial import inner membrane
FT                   translocase subunit TIM21"
FT                   /id="PRO_0000420931"
FT   TRANSMEM        130..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          88..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  30047 MW;  5488EF57160AEBC9 CRC64;
     MMMMNLLRRS AIAIGRQSKS KLASFSSATQ PCSGIPKSSK RVFSNSFLSK DSTGANGLLF
     RFRNPQASIC TEARPKNINS SYFTRSFASR TSKEPGNQQN KAKKEVTTVE DPFDSPTYHI
     PEKPVTFTEG ASYSLVILAG LGVAGAAGYG VFKELIFQPK EYKVFDKALK RIQDDGQVRV
     RIGSPIKGYG QETRNRAARQ RIPNRVFTDE DGVEHVEVNF YIRGPQGAGK VYTEMFKDKA
     EKEWKYTYLI VEILTPSPAK LMLESYLPA
 
 
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