ID   TIM21_DEBHA             Reviewed;         277 AA.
AC   Q6BVK1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM21;
DE   Flags: Precursor;
GN   Name=TIM21; OrderedLocusNames=DEHA2C02002g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane. Required to keep the TOM and
CC       the TIM23 complexes in close contact. At some point, it is released
CC       from the TOM23 complex to allow protein translocation into the
CC       mitochondrial matrix (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TIM23 complex, at least composed of TIM23,
CC       TIM17, TIM50 and TIM21. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TIM21 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG85804.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382135; CAG85804.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_457768.1; XM_457768.1.
DR   AlphaFoldDB; Q6BVK1; -.
DR   SMR; Q6BVK1; -.
DR   STRING; 4959.XP_457768.1; -.
DR   EnsemblFungi; CAG85804; CAG85804; DEHA2C02002g.
DR   GeneID; 2900066; -.
DR   KEGG; dha:DEHA2C02002g; -.
DR   eggNOG; KOG4836; Eukaryota.
DR   HOGENOM; CLU_089043_0_0_1; -.
DR   InParanoid; Q6BVK1; -.
DR   OrthoDB; 1330321at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:InterPro.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   Gene3D; 3.10.450.320; -; 1.
DR   InterPro; IPR013261; Tim21.
DR   InterPro; IPR038552; Tim21_IMS_sf.
DR   PANTHER; PTHR13032; PTHR13032; 1.
DR   Pfam; PF08294; TIM21; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Transit peptide; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..277
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit TIM21"
FT                   /id="PRO_0000043144"
FT   TOPO_DOM        ?..108
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..277
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          72..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..90
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  31037 MW;  3BE9EA3CE9F611D0 CRC64;
     MKSISTLGIC LRASQDLAKT RPISLLSTRS FANLTQGTST YHSLSIRSIR HNRLEARYTN
     ILNRNILPYK NYSTGTAPPP PPPPPPPHDK NAKGKFLFNR IGRAFTFSLS SVIVLGATCI
     SVLVVYLILS ELFLPSGDTR TFNKAVRMLE SNELAHEALG FKKGQRVKAH GEQHADKWAR
     NRPAQSVRTR GADGKDYLFM KFQVESPSGK YGTVTLEQVD RTFWSSEFLY IALDMPGNKR
     IYIKEPKFQS KKYVPKVGSL ASNDGFLGLK WGPKKDD