TIM21_GIBZE
ID TIM21_GIBZE Reviewed; 229 AA.
AC Q4HZ95; A0A0E0SH02; V6RP31;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit TIM21;
DE Flags: Precursor;
GN Name=TIM21; ORFNames=FGRRES_09713, FGSG_09713;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane. Required to keep the TOM and
CC the TIM23 complexes in close contact. At some point, it is released
CC from the TOM23 complex to allow protein translocation into the
CC mitochondrial matrix (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the TIM23 complex, at least composed of TIM23,
CC TIM17, TIM50 and TIM21. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TIM21 family. {ECO:0000305}.
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DR EMBL; DS231668; ESU16328.1; -; Genomic_DNA.
DR EMBL; HG970335; CEF85715.1; -; Genomic_DNA.
DR RefSeq; XP_011327988.1; XM_011329686.1.
DR AlphaFoldDB; Q4HZ95; -.
DR SMR; Q4HZ95; -.
DR STRING; 5518.FGSG_09713P0; -.
DR EnsemblFungi; ESU16328; ESU16328; FGSG_09713.
DR GeneID; 23556650; -.
DR KEGG; fgr:FGSG_09713; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G26449; -.
DR eggNOG; KOG4836; Eukaryota.
DR HOGENOM; CLU_089407_0_0_1; -.
DR InParanoid; Q4HZ95; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:InterPro.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR Gene3D; 3.10.450.320; -; 1.
DR InterPro; IPR013261; Tim21.
DR InterPro; IPR038552; Tim21_IMS_sf.
DR PANTHER; PTHR13032; PTHR13032; 1.
DR Pfam; PF08294; TIM21; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Transit peptide; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..31
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 32..229
FT /note="Mitochondrial import inner membrane translocase
FT subunit TIM21"
FT /id="PRO_0000043145"
FT TOPO_DOM 32..76
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..229
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
SQ SEQUENCE 229 AA; 26006 MW; 97E68FC87CBFC728 CRC64;
MNPTTNLLVT RSTAFRGVPT TLRPFLASRY YATQQGLGAT PRGPKRRAVT PFNDNGHVPW
KQLSVAEKAA RATQQSFNFG MILVGLMLTG GVGYFLWTDV FSPDSKISNF NRAVDKIRSD
PRIIDVMGDS KKIAAHGDET FNKWRRARPV ASSETTDARG DQHIMMHFYV EGPKNNGVAR
LHMIKYRGHS DFEYKYLFVD VKDHERIYLE HEDSSSKNGK KFSLFGVKW
