ID   TIM21_PONAB             Reviewed;         172 AA.
AC   Q5REP2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim21;
DE   AltName: Full=TIM21-like protein, mitochondrial;
DE   Flags: Precursor;
GN   Name=TIMM21; Synonyms=TIM21;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the translocation of transit peptide-
CC       containing proteins across the mitochondrial inner membrane. Also
CC       required for assembly of mitochondrial respiratory chain complex I and
CC       complex IV as component of the MITRAC (mitochondrial translation
CC       regulation assembly intermediate of cytochrome c oxidase complex)
CC       complex. Probably shuttles between the presequence translocase and
CC       respiratory-chain assembly intermediates in a process that promotes
CC       incorporation of early nuclear-encoded subunits into these complexes.
CC       {ECO:0000250|UniProtKB:Q9BVV7}.
CC   -!- SUBUNIT: Component of the TIM23 complex. Component of the MITRAC
CC       (mitochondrial translation regulation assembly intermediate of
CC       cytochrome c oxidase complex) complex, the core components of this
CC       complex being COA3/MITRAC12 and COX14. Interacts with COA3 AND MT-
CC       CO1/COX1. {ECO:0000250|UniProtKB:Q9BVV7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TIM21 family. {ECO:0000305}.
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DR   EMBL; CR857480; CAH89765.1; -; mRNA.
DR   RefSeq; NP_001127193.1; NM_001133721.1.
DR   AlphaFoldDB; Q5REP2; -.
DR   STRING; 9601.ENSPPYP00000010367; -.
DR   GeneID; 100174247; -.
DR   KEGG; pon:100174247; -.
DR   CTD; 29090; -.
DR   eggNOG; KOG4836; Eukaryota.
DR   InParanoid; Q5REP2; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; ISS:UniProtKB.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; ISS:UniProtKB.
DR   InterPro; IPR013261; Tim21.
DR   PANTHER; PTHR13032; PTHR13032; 1.
DR   Pfam; PF08294; TIM21; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Protein transport; Reference proteome;
KW   Transit peptide; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   TRANSIT         1..18
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..172
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim21"
FT                   /id="PRO_0000043230"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          68..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19287 MW;  D9C96CCB0F4E0176 CRC64;
     MICTFLRAVQ YTEKLHRSLA KRLLLPHIVL NKACLKTEPS LRCRLQYQKK TVLPRCILGV
     TQKTIWTQGP SPGKAKEDSS KQVSVHRSQR GGTAVPTSQK VKEAGRDFTY LIVVLFGISI
     TGGLFYTIFK ELFSSSSPSK IYGRALEKCR SHPEGRSSHR PRSDVIARIC SP