TIM21_SCHPO
ID TIM21_SCHPO Reviewed; 223 AA.
AC O94618;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit tim21;
DE Flags: Precursor;
GN Name=tim21; ORFNames=SPBC1289.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane. Required to keep the TOM and
CC the TIM23 complexes in close contact. At some point, it is released
CC from the TOM23 complex to allow protein translocation into the
CC mitochondrial matrix (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the TIM23 complex, at least composed of tim23,
CC tim17, tim50 and tim21. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TIM21 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB38689.1; -; Genomic_DNA.
DR PIR; T39360; T39360.
DR RefSeq; NP_596833.1; NM_001023854.2.
DR AlphaFoldDB; O94618; -.
DR SMR; O94618; -.
DR BioGRID; 276525; 10.
DR ComplexPortal; CPX-540; Mitochondrial inner membrane pre-sequence translocase complex.
DR STRING; 4896.SPBC1289.09.1; -.
DR MaxQB; O94618; -.
DR PaxDb; O94618; -.
DR EnsemblFungi; SPBC1289.09.1; SPBC1289.09.1:pep; SPBC1289.09.
DR GeneID; 2539981; -.
DR KEGG; spo:SPBC1289.09; -.
DR PomBase; SPBC1289.09; tim21.
DR VEuPathDB; FungiDB:SPBC1289.09; -.
DR eggNOG; KOG4836; Eukaryota.
DR HOGENOM; CLU_1240758_0_0_1; -.
DR InParanoid; O94618; -.
DR OMA; KAYRTSA; -.
DR PhylomeDB; O94618; -.
DR PRO; PR:O94618; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IC:ComplexPortal.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; ISO:PomBase.
DR Gene3D; 3.10.450.320; -; 1.
DR InterPro; IPR013261; Tim21.
DR InterPro; IPR038552; Tim21_IMS_sf.
DR PANTHER; PTHR13032; PTHR13032; 1.
DR Pfam; PF08294; TIM21; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Transit peptide; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..23
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 24..223
FT /note="Mitochondrial import inner membrane translocase
FT subunit tim21"
FT /id="PRO_0000043165"
FT TOPO_DOM 24..74
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..223
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
SQ SEQUENCE 223 AA; 25568 MW; 7CAAAC9D2417F9FE CRC64;
MIRTIQRQSA TRFSSALVQR RLYSLASDSL NKQRKPQEEG RLARIFKDPS NKAWKDLTAP
QKAYRTSANI GNFSIVIFGG GVFGLIIYAL VTSIWKGEAH YGDEAFELLK ANEECRYVFG
DHMKALGEAT HPLRRTHGIL TSRVWDHHGV EHLVLQFHLI GNERKGHVFG RLVNVQGDYK
WEYLFVDVAN YGKIIIFDHT NSVRQQHKNF GLWGSLKNIT WGN
