ID   TIM21_XENLA             Reviewed;         232 AA.
AC   Q5XKA2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim21;
DE   AltName: Full=TIM21-like protein, mitochondrial;
DE   Flags: Precursor;
GN   Name=timm21; Synonyms=tim21;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the translocation of transit peptide-
CC       containing proteins across the mitochondrial inner membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TIM21 family. {ECO:0000305}.
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DR   EMBL; BC083009; AAH83009.1; -; mRNA.
DR   RefSeq; NP_001088133.1; NM_001094664.1.
DR   AlphaFoldDB; Q5XKA2; -.
DR   SMR; Q5XKA2; -.
DR   GeneID; 494838; -.
DR   KEGG; xla:494838; -.
DR   CTD; 494838; -.
DR   Xenbase; XB-GENE-1009773; timm21.L.
DR   OrthoDB; 1330321at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 494838; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:InterPro.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   Gene3D; 3.10.450.320; -; 1.
DR   InterPro; IPR013261; Tim21.
DR   InterPro; IPR038552; Tim21_IMS_sf.
DR   PANTHER; PTHR13032; PTHR13032; 1.
DR   Pfam; PF08294; TIM21; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Protein transport; Reference proteome;
KW   Transit peptide; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   TRANSIT         1..31
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..232
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim21"
FT                   /id="PRO_0000043168"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   232 AA;  26066 MW;  D6090EF15140DD30 CRC64;
     MLPRFLWRPV LCSYRALGSP SRSLTVSYRN LSCLALLHKG AFAAPTSRSL FCAERPISTG
     CTSLQVKDKR VSVQSTSDGA PPQNASHKVK EAGRDFTYFI VVLIGIGVTG GLFYVVFEEL
     FSSSSPSKIY GEALEKCRSH PEVIGAFGEP IKGYGETTRR GRRQHVSHME FVKDGIKCMR
     LKFYIEGSEP RKQGTVHIEV KENPASGKYE FQYIFVEIDT YPRRTIIIED NR