TIM22_CAEEL
ID TIM22_CAEEL Reviewed; 213 AA.
AC Q9NAQ9;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit tim-22;
GN ORFNames=C47G2.3 {ECO:0000312|WormBase:C47G2.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Essential core component of the TIM22 complex, a complex that
CC mediates the import and insertion of multi-pass transmembrane proteins
CC into the mitochondrial inner membrane. In the TIM22 complex, it
CC constitutes the voltage-activated and signal-gated channel. Forms a
CC twin-pore translocase that uses the membrane potential as external
CC driving force in 2 voltage-dependent steps (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the TIM22 complex, whose core is composed of tim-
CC 22, associated with the 70 kDa heterohexamer. In most cases, the 70 kDa
CC complex is composed of tim-9/tin-9.1 and tim-10/tin-10 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; Z49125; CAB97233.1; -; Genomic_DNA.
DR RefSeq; NP_496412.1; NM_064011.3.
DR AlphaFoldDB; Q9NAQ9; -.
DR SMR; Q9NAQ9; -.
DR STRING; 6239.C47G2.3; -.
DR EPD; Q9NAQ9; -.
DR PaxDb; Q9NAQ9; -.
DR PeptideAtlas; Q9NAQ9; -.
DR EnsemblMetazoa; C47G2.3.1; C47G2.3.1; WBGene00008164.
DR GeneID; 174722; -.
DR KEGG; cel:CELE_C47G2.3; -.
DR UCSC; C47G2.3.1; c. elegans.
DR CTD; 174722; -.
DR WormBase; C47G2.3; CE25820; WBGene00008164; -.
DR eggNOG; KOG3225; Eukaryota.
DR GeneTree; ENSGT00390000016067; -.
DR HOGENOM; CLU_091077_0_0_1; -.
DR InParanoid; Q9NAQ9; -.
DR OMA; QGMESCA; -.
DR OrthoDB; 1544601at2759; -.
DR PhylomeDB; Q9NAQ9; -.
DR PRO; PR:Q9NAQ9; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00008164; Expressed in larva and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042721; C:TIM22 mitochondrial import inner membrane insertion complex; IBA:GO_Central.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR InterPro; IPR039175; TIM22.
DR PANTHER; PTHR14110; PTHR14110; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..213
FT /note="Mitochondrial import inner membrane translocase
FT subunit tim-22"
FT /id="PRO_0000228084"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 213 AA; 23462 MW; 8B1F02C80A9A425E CRC64;
MALASSNATS MEELFGNPFR PKKERVVVEE KPFEYTPSAY VQMIDQMIGI KTRPWNPERT
PIKPIQMLTL PEMSREERWI QWGMENCTVK ASISGVLGVG VGFAFGLFTA SVDPQLSMVG
GDPTKQLTLK QTWKEMSSRM KSYGKNFGSI GLMFSGTECA LETIRAKSDW RNGTYSGGIV
GGLLGLRAGI MPAVWGAAGF AVFSTIIDHY MRG
