TIM23_RAT
ID TIM23_RAT Reviewed; 209 AA.
AC O35093;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit Tim23;
GN Name=Timm23; Synonyms=Tim23;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=9538267; DOI=10.1093/oxfordjournals.jbchem.a021997;
RA Ishihara N., Mihara K.;
RT "Identification of the protein import components of the rat mitochondrial
RT inner membrane, rTIM17, rTIM23, and rTIM44.";
RL J. Biochem. 123:722-732(1998).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane.
CC {ECO:0000250|UniProtKB:O14925}.
CC -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly
CC interacts with TIMM50. The complex interacts with the TIMM44 component
CC of the PAM complex and with DNAJC15. {ECO:0000250|UniProtKB:O14925}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O14925}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; AB006451; BAA21819.1; -; mRNA.
DR PIR; JE0154; JE0154.
DR RefSeq; NP_062225.1; NM_019352.2.
DR AlphaFoldDB; O35093; -.
DR SMR; O35093; -.
DR CORUM; O35093; -.
DR STRING; 10116.ENSRNOP00000026932; -.
DR jPOST; O35093; -.
DR PaxDb; O35093; -.
DR PRIDE; O35093; -.
DR GeneID; 54312; -.
DR KEGG; rno:54312; -.
DR UCSC; RGD:3863; rat.
DR CTD; 100287932; -.
DR RGD; 3863; Timm23.
DR eggNOG; KOG3324; Eukaryota.
DR InParanoid; O35093; -.
DR OrthoDB; 1418527at2759; -.
DR PhylomeDB; O35093; -.
DR PRO; PR:O35093; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISO:RGD.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; ISO:RGD.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IMP:RGD.
DR GO; GO:0010954; P:positive regulation of protein processing; IMP:RGD.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:1905242; P:response to 3,3',5-triiodo-L-thyronine; IEP:RGD.
DR InterPro; IPR005681; Tim23.
DR InterPro; IPR045238; Tim23-like.
DR PANTHER; PTHR15371; PTHR15371; 1.
DR TIGRFAMs; TIGR00983; 3a0801s02tim23; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..209
FT /note="Mitochondrial import inner membrane translocase
FT subunit Tim23"
FT /id="PRO_0000210304"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..197
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 209 AA; 21907 MW; 54D3A8749F6EF21F CRC64;
MEGGGGSSNK STGGLAGFFG AGGAGYSNAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF
ILPTGANKTR GRFELAFFTI GGCCMTGAAF GALNGLRLGL KETQSMPWSK PRNVQILNMV
TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDFNTVAA GTMTGMLYKC TGGLRGIARG
GLAGLTLTSV YALYNNWEHM KGSLLQQSL
