TIM23_SCHPO
ID TIM23_SCHPO Reviewed; 210 AA.
AC Q9USM7;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit tim23;
GN Name=tim23; ORFNames=SPCC16A11.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane. {ECO:0000250}.
CC -!- SUBUNIT: Component of the TIM23 complex, at least composed of tim23,
CC tim17, tim50 and tim21. The complex interacts with the tim44 component
CC of the PAM complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; CU329672; CAB53081.1; -; Genomic_DNA.
DR PIR; T41082; T41082.
DR RefSeq; NP_587996.1; NM_001022987.2.
DR AlphaFoldDB; Q9USM7; -.
DR BioGRID; 275365; 1.
DR ComplexPortal; CPX-540; Mitochondrial inner membrane pre-sequence translocase complex.
DR STRING; 4896.SPCC16A11.09c.1; -.
DR MaxQB; Q9USM7; -.
DR PaxDb; Q9USM7; -.
DR EnsemblFungi; SPCC16A11.09c.1; SPCC16A11.09c.1:pep; SPCC16A11.09c.
DR GeneID; 2538784; -.
DR KEGG; spo:SPCC16A11.09c; -.
DR PomBase; SPCC16A11.09c; tim23.
DR VEuPathDB; FungiDB:SPCC16A11.09c; -.
DR eggNOG; KOG3324; Eukaryota.
DR HOGENOM; CLU_063935_0_0_1; -.
DR InParanoid; Q9USM7; -.
DR OMA; GVRPMMI; -.
DR PhylomeDB; Q9USM7; -.
DR Reactome; R-SPO-1268020; Mitochondrial protein import.
DR PRO; PR:Q9USM7; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IC:ComplexPortal.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; ISO:PomBase.
DR InterPro; IPR005681; Tim23.
DR InterPro; IPR045238; Tim23-like.
DR PANTHER; PTHR15371; PTHR15371; 1.
DR TIGRFAMs; TIGR00983; 3a0801s02tim23; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..210
FT /note="Mitochondrial import inner membrane translocase
FT subunit tim23"
FT /id="PRO_0000210306"
FT TRANSMEM 87..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 210 AA; 22622 MW; B3DE18FC830C538A CRC64;
MSWLFTRNKE EEPTSKIDSS ELQVPTEATA SDILSGSEFD PAKLHPLADL DKPLDYLLIE
EDALSTLPGD SMAIPSRGWQ DDLCYGTGTS YLSGLAIGGL WGLNEGMKKT KDITSTRLRL
NGILNGVTRR GPFVGNSLGV LALVYNGINS LIGYKRQKHG WENSVAAGAL TGALYKSTRG
LRAMAISSSL VATAAGIWTL AKRSFTKRLN
