ID   TIM23_XENTR             Reviewed;         209 AA.
AC   Q5XH94;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim23;
GN   Name=timm23; Synonyms=timm23b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane.
CC       {ECO:0000250|UniProtKB:O14925}.
CC   -!- SUBUNIT: Component of the TIM23 complex at least composed of timm23,
CC       timm17 and timm50. The complex interacts with the timm44 component of
CC       the PAM complex (By similarity). {ECO:0000250|UniProtKB:O14925}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O14925}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; BC084178; AAH84178.1; -; mRNA.
DR   RefSeq; NP_001011053.1; NM_001011053.1.
DR   AlphaFoldDB; Q5XH94; -.
DR   SMR; Q5XH94; -.
DR   STRING; 8364.ENSXETP00000055332; -.
DR   DNASU; 496463; -.
DR   Ensembl; ENSXETT00000060802; ENSXETP00000063771; ENSXETG00000026175.
DR   GeneID; 496463; -.
DR   KEGG; xtr:496463; -.
DR   CTD; 100287932; -.
DR   Xenbase; XB-GENE-994532; timm23.
DR   eggNOG; KOG3324; Eukaryota.
DR   InParanoid; Q5XH94; -.
DR   OrthoDB; 1418527at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026175; Expressed in egg cell and 22 other tissues.
DR   ExpressionAtlas; Q5XH94; differential.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   InterPro; IPR005681; Tim23.
DR   InterPro; IPR045238; Tim23-like.
DR   PANTHER; PTHR15371; PTHR15371; 1.
DR   TIGRFAMs; TIGR00983; 3a0801s02tim23; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..209
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim23"
FT                   /id="PRO_0000354677"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   209 AA;  21842 MW;  0D76670900C0947F CRC64;
     MDTNHPGSAG GRGGLGSIFG GGSPGYSHSD LAGVPLTGMS PLSPYLNVDP RYLVQDNDEF
     ILPTGANKTR GRFELAFFTI GGCCMSGAAF GAVNGLRLGF KETQNMAWSK PKNVQILNMV
     TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTIAA GTMTGMLYKS TGGLRGVARG
     GLAGLALTSA FALYNNWEHI KGSSSRLSL