BSHC_STAAS
ID BSHC_STAAS Reviewed; 537 AA.
AC Q6GA35;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=SAS1111;
OS Staphylococcus aureus (strain MSSA476).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282459;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSSA476;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC last step of the pathway, the addition of cysteine to glucosamine
CC malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC Rule:MF_01867}.
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DR EMBL; BX571857; CAG42888.1; -; Genomic_DNA.
DR RefSeq; WP_000340475.1; NC_002953.3.
DR AlphaFoldDB; Q6GA35; -.
DR SMR; Q6GA35; -.
DR KEGG; sas:SAS1111; -.
DR HOGENOM; CLU_022249_0_0_9; -.
DR OMA; TTGHQLN; -.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01867; BshC; 1.
DR InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR Pfam; PF10079; BshC; 1.
DR PIRSF; PIRSF012535; UCP012535; 1.
DR TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE 3: Inferred from homology;
KW Coiled coil; Ligase.
FT CHAIN 1..537
FT /note="Putative cysteine ligase BshC"
FT /id="PRO_0000378257"
FT COILED 422..450
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ SEQUENCE 537 AA; 62807 MW; 7D79964314F46AA4 CRC64;
MDCKVVSLNE KDQFIPKIKS SDPVITGLFQ YDAAQQTSFE KRMSKENNGR EAALANVIRE
YMSDLKLSSE QELNIQHLAN GSKVVIGGQQ AGLFGGPLYT FHKIFSIITL SKELTDTHKQ
QVVPVFWIAG EDHDFDEVNH TFVYNENHGS LHKVKYHTME MPETTVSRYY PDKAELKQTL
KTMFIHMKET VHTQGLLEIC DRIIDQYDSW TDMFKALLHE TFKAYGVLFI DAQFEPLRKM
EAPMFKKILK KHQLLDDAFR ATQQRTQNQG LNAMIQTDTN VHLFLHDENM RQLVSYDGKH
FKLNKTDKTY IKEEIINIAE NQPELFSNNV VTRPLMEEWL FNTVAFVGGP SEIKYWAELK
DVFELFDVEM PIVMPRLRIT YLNDRIEKLL SKYNIPLEKV LVDGVEGERS KFIREQASHQ
FIEKVEGMIE QQRRLNKDLL DEVAGNQNNI NLVNKNNEIH IQQYDYLLKR YLLNIEREND
ISMKQFREIQ ETLHPMGGLQ ERIWNPLQIL NDFGTDVFKP STYPPLSYTF DHIIIKP