ID   BSHC_STACT              Reviewed;         537 AA.
AC   B9DPQ7;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=Sca_0790;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; AM295250; CAL27700.1; -; Genomic_DNA.
DR   RefSeq; WP_015900042.1; NC_012121.1.
DR   AlphaFoldDB; B9DPQ7; -.
DR   SMR; B9DPQ7; -.
DR   STRING; 396513.SCA_0790; -.
DR   GeneID; 60545511; -.
DR   KEGG; sca:SCA_0790; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   BioCyc; SCAR396513:SCA_RS04005-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase.
FT   CHAIN           1..537
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378266"
FT   COILED          417..457
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   537 AA;  62744 MW;  7D149CF2A8EF2DAC CRC64;
     MDCLIANINE NDQFLERLKE SESLLNTFYQ YDAMSPESFE QALNAPNNGR EQELASVISN
     YMSDLELTEA QQINIDKLKK GAKVVIGGQQ AGLFGGPLYT FHKILSIVNL SRQLNEEYNK
     EVVPVFWIAG EDHDFDEVNH TYVFNTEKAK LHKVKYHTMT PPESNVSRFI PDKDKMLEAL
     DDFLVQIPET AHTNHLRNEV QHIIKNYASW SDMFKALLHI VFKEYGVLLI DAQDPKLRHL
     EKPILKEMLK KHDEVDRAFR QRQAETVEAG LAEMIQTDTN VHLFLHEDDM RQLLTYEDGH
     YYTSKSQTAY TLDELLEIVE NTPERFSNNV VTRPIMEEWL FNTVSFIGGP SEIKYWAELK
     AAFDVLDVTM PIVLPRMKIT YITKRIEKLL KRYDINAEHV IADGIDNDKN KFIRAHASEQ
     FLNELDQLEA QQKETYERLA AEVQGNEDNK NLVEKNNQIH QSQYDYLRKR YFINIERENA
     ISMKHFRELN ETLHPMGGLQ ERVWNALQFM NEFGTDMFSP SIYPPLRYTL KQIIIKP