ID   BSHC_STAEQ              Reviewed;         537 AA.
AC   Q5HQ15;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=SERP0742;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; CP000029; AAW54122.1; -; Genomic_DNA.
DR   RefSeq; WP_002486271.1; NC_002976.3.
DR   AlphaFoldDB; Q5HQ15; -.
DR   SMR; Q5HQ15; -.
DR   STRING; 176279.SERP0742; -.
DR   EnsemblBacteria; AAW54122; AAW54122; SERP0742.
DR   KEGG; ser:SERP0742; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase; Reference proteome.
FT   CHAIN           1..537
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378268"
FT   COILED          415..439
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   537 AA;  63492 MW;  D7F6F01022C84B01 CRC64;
     MKCNTLKLTE QDQFINKIKN SESQITSFYE YDASQKESFD RRLKTPNNGR EFHLSRVIKS
     YMNELNLTHQ QLNNIDALAD GAKVVIGGQQ AGLFGGPLYT FHKIFSIIIL SRQLSEKYDT
     PIVPVFWIAG EDHDFEEVNH TYAFNNKETT LKKVKYHTMT PPDSNVSRYT PDKNELKASL
     NHFFKEIKET VHTQDVYQMC VNIINQYDSW TDIFKGLIHE VFKDYGILLI DAQYPELRQM
     EKPLFKEILE KRDQVDQSFR ETQIRTTQQQ LPSMIQTETN THLFIHEDGM RQLLNFDGTY
     FKLNKTEKRY TKQNLLDIIE REPERISNNV VTRPVVEEWL FNTVAFIGGP SEIKYWAELK
     GVFDTLNVEM PIVMPRLRIT YLYARTKKLL KQYNLSIESV IANGVEQERQ RFVREKASNN
     FINEVEEMKT QQQELYNNLL TYVENNHDNQ LLLEKNNQIH LNQYDYLIKR YLLNIEREND
     ISMRQFREIS ETLHPMGGLQ ERVWNPLQIM NDFGIDVFSP STYPPLSYSF DHLIIKH