ID   BSHC_STAES              Reviewed;         537 AA.
AC   Q8CSX9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=SE_0852;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; AE015929; AAO04449.1; -; Genomic_DNA.
DR   RefSeq; NP_764407.1; NC_004461.1.
DR   RefSeq; WP_002485008.1; NZ_WBME01000036.1.
DR   AlphaFoldDB; Q8CSX9; -.
DR   SMR; Q8CSX9; -.
DR   STRING; 176280.SE_0852; -.
DR   EnsemblBacteria; AAO04449; AAO04449; SE_0852.
DR   KEGG; sep:SE_0852; -.
DR   PATRIC; fig|176280.10.peg.825; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase.
FT   CHAIN           1..537
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378267"
FT   COILED          415..439
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   537 AA;  63648 MW;  77481613DBFD8C05 CRC64;
     MKCNTLKLTE QDQFINKIKN SESQITSFYE YDAAKKESFY RRLKTPNNGR EFHLSRVIKS
     YMNELKLTHQ QLNNIDALAD GAKVVIGGQQ AGLFGGPLYT FHKIFSIITL SRQLSEEYDT
     PIVPVFWIAG EDHDFEEVNH TYAFNNKETT LKKVKYHTMT PPDSNVSRYT PDKNELKASL
     NHFFKEMKET VHTQDVYQMC VNIINQFDSW TDIFKGLIHE VFKDYGILFI DAQYPELRQM
     EKPLFKEILE KRNQIDQSFR ETQIRKTQQQ LPSMIQTETN THLFIHEDGM RQLLNFDGTY
     FKLNKTEKRY TKQNLLDIIE REPERISNNV VTRPVVEEWL FNTVAFIGGP SEIKYWAELK
     DVFDTLNVEM PIVMPRLRIT YLYARTKKLL KQYNLSIESV IANGVEQERQ HFVREKASNN
     FINEVEEMKI QQQELYNNLF TYVENNHDNQ LLLEKNNQIH LNQYDYLIKR YLLNIEREND
     ISMRQFREIS ETLHPMGGLQ ERVWNPLQIM NDFGIDVFSP TTYPPLSYSF DHLIINP