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TIM9_CAEEL
ID   TIM9_CAEEL              Reviewed;          90 AA.
AC   Q17754; Q86B35;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim9;
GN   Name=tin-9.1; Synonyms=tim9a, tin-9; ORFNames=C06G3.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX   PubMed=10611480; DOI=10.1016/s0014-5793(99)01665-8;
RA   Bauer M.F., Rothbauer U., Muehlenbein N., Smith R.J.H., Gerbitz K.-D.,
RA   Neupert W., Brunner M., Hofmann S.;
RT   "The mitochondrial TIM22 preprotein translocase is highly conserved
RT   throughout the eukaryotic kingdom.";
RL   FEBS Lett. 464:41-47(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=15485840; DOI=10.1074/jbc.m409618200;
RA   Curran S.P., Leverich E.P., Koehler C.M., Larsen P.L.;
RT   "Defective mitochondrial protein translocation precludes normal
RT   Caenorhabditis elegans development.";
RL   J. Biol. Chem. 279:54655-54662(2004).
CC   -!- FUNCTION: Mitochondrial intermembrane chaperone that participates in
CC       the import and insertion of multi-pass transmembrane proteins into the
CC       mitochondrial inner membrane. May also be required for the transfer of
CC       beta-barrel precursors from the TOM complex to the sorting and assembly
CC       machinery (SAM complex) of the outer membrane. Acts as a chaperone-like
CC       protein that protects the hydrophobic precursors from aggregation and
CC       guide them through the mitochondrial intermembrane space (Probable).
CC       {ECO:0000305|PubMed:15485840}.
CC   -!- SUBUNIT: Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3
CC       copies of tim-10/tin-10, named soluble 70 kDa complex. The complex
CC       associates with the tim-22 component of the TIM22 complex. Interacts
CC       with multi-pass transmembrane proteins in transit (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Intermembrane side
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q17754-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q17754-2; Sequence=VSP_015407;
CC   -!- DOMAIN: The twin CX3C motif contains 4 conserved Cys residues that form
CC       2 disulfide bonds in the mitochondrial intermembrane space. However,
CC       during the transit of tim-9/tin-9.1 from cytoplasm into mitochondrion,
CC       the Cys residues probably coordinate zinc, thereby preventing folding
CC       and allowing its transfer across mitochondrial outer membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Worms display a small body size, reduced number
CC       of progeny produced and partial embryonic lethality due to defects in
CC       import of proteins into mitochondria. {ECO:0000269|PubMed:15485840}.
CC   -!- SIMILARITY: Belongs to the small Tim family. {ECO:0000305}.
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DR   EMBL; AF150108; AAD40014.1; -; mRNA.
DR   EMBL; FO080396; CCD83559.1; -; Genomic_DNA.
DR   EMBL; FO080396; CCD83560.1; -; Genomic_DNA.
DR   PIR; T30100; T30100.
DR   RefSeq; NP_001021307.1; NM_001026136.3. [Q17754-2]
DR   RefSeq; NP_501094.1; NM_068693.1.
DR   AlphaFoldDB; Q17754; -.
DR   SMR; Q17754; -.
DR   BioGRID; 42594; 3.
DR   STRING; 6239.C06G3.11a; -.
DR   EPD; Q17754; -.
DR   PaxDb; Q17754; -.
DR   PeptideAtlas; Q17754; -.
DR   EnsemblMetazoa; C06G3.11.1; C06G3.11.1; WBGene00006572. [Q17754-2]
DR   GeneID; 177475; -.
DR   KEGG; cel:CELE_C06G3.11; -.
DR   UCSC; C06G3.11a; c. elegans. [Q17754-1]
DR   CTD; 177475; -.
DR   WormBase; C06G3.11; CE33518; WBGene00006572; tin-9.1. [Q17754-2]
DR   eggNOG; KOG3479; Eukaryota.
DR   GeneTree; ENSGT00940000160102; -.
DR   InParanoid; Q17754; -.
DR   OMA; QDFLRMY; -.
DR   OrthoDB; 1627953at2759; -.
DR   PhylomeDB; Q17754; -.
DR   PRO; PR:Q17754; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006572; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IMP:WormBase.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; IMP:WormBase.
DR   GO; GO:0000003; P:reproduction; IMP:WormBase.
DR   Gene3D; 1.10.287.810; -; 1.
DR   InterPro; IPR004217; Tim10-like.
DR   InterPro; IPR035427; Tim10-like_dom_sf.
DR   Pfam; PF02953; zf-Tim10_DDP; 1.
DR   SUPFAM; SSF144122; SSF144122; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Chaperone; Disulfide bond; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Translocation; Transport; Zinc.
FT   CHAIN           1..90
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim9"
FT                   /id="PRO_0000193601"
FT   MOTIF           24..48
FT                   /note="Twin CX3C motif"
FT   DISULFID        24..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        28..44
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         78..90
FT                   /note="IKVENGGKINKIQ -> M (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_015407"
SQ   SEQUENCE   90 AA;  10193 MW;  1CAD15DFD58A1DE4 CRC64;
     MTSEQNIQTF RDFLTQYNLV AEQCFNSCVN EFGSRTVSGK EESCANNCLD KFLKMTQRVS
     QRFQEHQLLN AQANGAAIKV ENGGKINKIQ
 
 
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