ID   BSHC_STAS1              Reviewed;         537 AA.
AC   Q49WV9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=SSP1594;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
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DR   EMBL; AP008934; BAE18739.1; -; Genomic_DNA.
DR   RefSeq; WP_011303331.1; NZ_MTGA01000034.1.
DR   AlphaFoldDB; Q49WV9; -.
DR   SMR; Q49WV9; -.
DR   STRING; 342451.SSP1594; -.
DR   EnsemblBacteria; BAE18739; BAE18739; SSP1594.
DR   KEGG; ssp:SSP1594; -.
DR   PATRIC; fig|342451.11.peg.1596; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Ligase; Reference proteome.
FT   CHAIN           1..537
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378270"
SQ   SEQUENCE   537 AA;  62816 MW;  F3775520C26A2ACA CRC64;
     MDCMITKLNE KDQFISKIKD SDSKIGQFYH FDAMQEKSYS ERLSMSNNGR EVALAQVIKN
     YMSDLTLTEK QLQNISLLSE GAKVIIGGQQ AGLFGGPLYT FHKIFSIITM SEKLSKDYNT
     NVIPVFWIAG EDHDFDEVNH TYAYNAQNAK LQKIKYHTMT PPEASVSTYY PDKAQLKDAL
     KLFFKEMNET THSKQMIEMC TKIIDQYDSW TDMFKALLNE VFKAYGLLLI DANNTELRKL
     EQPFIQKIIE HHQDVDASFR NNQQNTIANG LEQMIQTDTN VHLFLHEDNM RQLLTFKDNQ
     FYLSKSDKYM TKEELLKILE VEPERFSNNV VTRPIMEEWL FNTVAFIGGP SEIKYWTELS
     EVFNTLDVSM PIVLPRLRIS YLYPRTEKLL SQYQLKQHSI IEQGIEKDKE KFIRAQASQT
     FVDKVEEIKV QQEKLYQSLL TEVAGNNDNQ LLVEKNNHIH QKQYEYLINR YLLNIERKNE
     ISMKHFKELS ETLHPMGGLQ ERIWNPLQIM NDFGIDVFSP STYPPLSYTF DHIIVKP